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A normative model of serum inhibin B in young males
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dc.contributor.author | Kelsey, Thomas William | |
dc.contributor.author | Miles, Amy | |
dc.contributor.author | Mitchell, Rod T. | |
dc.contributor.author | Anderson, Richard | |
dc.contributor.author | Wallace, W. Hamish B. | |
dc.date.accessioned | 2016-04-15T15:52:19Z | |
dc.date.available | 2016-04-15T15:52:19Z | |
dc.date.issued | 2016-04-14 | |
dc.identifier | 241750814 | |
dc.identifier | 94a4dac0-632e-45ff-ad58-d66f05ee0047 | |
dc.identifier | 27077369 | |
dc.identifier | 84964344741 | |
dc.identifier | 27077369 | |
dc.identifier | 000374131700113 | |
dc.identifier.citation | Kelsey , T W , Miles , A , Mitchell , R T , Anderson , R & Wallace , W H B 2016 , ' A normative model of serum inhibin B in young males ' , PLoS One , vol. 11 , no. 4 , e0153843 . https://doi.org/10.1371/journal.pone.0153843 | en |
dc.identifier.issn | 1932-6203 | |
dc.identifier.other | PubMedCentral: PMC4831823 | |
dc.identifier.other | ORCID: /0000-0002-8091-1458/work/27201531 | |
dc.identifier.uri | https://hdl.handle.net/10023/8617 | |
dc.description | RTM is supported by a Wellcome Trust Intermediate Clinical Fellowship (Grant No: 098522). | en |
dc.description.abstract | Inhibin B has been identified as a potential marker of Sertoli cell function in males. The aim of this study is to produce a normative model of serum inhibin B in males from birth to seventeen years. We used a well-defined search strategy to identify studies containing data that can contribute to a larger approximation of the healthy population. We combined data from four published studies (n = 709) and derived an internally validated model with high goodness-of-fit and normally distributed residuals. Our results show that inhibin B increases following birth to a post-natal peak of 270 pg/mL (IQR 210–335 pg/mL) and then decreases during childhood followed by a rise at around 8 years, peaking at a mean 305 pg/mL (IQR 240–445 pg/mL) at around age 17. Following this peak there is a slow decline to the standard mature adult normal range of 170 pg/mL (IQR 125–215 pg/mL). This normative model suggests that 35% of the variation in Inhibin B levels in young males is due to age alone, provides an age-specific reference range for inhibin B in the young healthy male population, and will be a powerful tool in evaluating the potential of inhibin B as a marker of Sertoli cell function in pre-pubertal boys. | |
dc.format.extent | 10 | |
dc.format.extent | 1257662 | |
dc.language.iso | eng | |
dc.relation.ispartof | PLoS One | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Biomarkers | en |
dc.subject | Blood Chemical Analysis | en |
dc.subject | Child | en |
dc.subject | Child, Preschool | en |
dc.subject | Humans | en |
dc.subject | Infant | en |
dc.subject | Infant, Newborn | en |
dc.subject | Inhibins | en |
dc.subject | Male | en |
dc.subject | Reference Values | en |
dc.subject | Journal Article | en |
dc.subject | Research Support, Non-U.S. Gov't | en |
dc.subject | RJ101 Child Health. Child health services | en |
dc.subject | NDAS | en |
dc.subject.lcc | RJ101 | en |
dc.title | A normative model of serum inhibin B in young males | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Computer Science | en |
dc.contributor.institution | University of St Andrews. Centre for Interdisciplinary Research in Computational Algebra | en |
dc.identifier.doi | 10.1371/journal.pone.0153843 | |
dc.description.status | Peer reviewed | en |
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