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dc.contributor.authorKelsey, Thomas William
dc.contributor.authorMiles, Amy
dc.contributor.authorMitchell, Rod T.
dc.contributor.authorAnderson, Richard
dc.contributor.authorWallace, W. Hamish B.
dc.date.accessioned2016-04-15T15:52:19Z
dc.date.available2016-04-15T15:52:19Z
dc.date.issued2016-04-14
dc.identifier.citationKelsey , T W , Miles , A , Mitchell , R T , Anderson , R & Wallace , W H B 2016 , ' A normative model of serum inhibin B in young males ' , PLoS One , vol. 11 , no. 4 , e0153843 . https://doi.org/10.1371/journal.pone.0153843en
dc.identifier.issn1932-6203
dc.identifier.otherPURE: 241750814
dc.identifier.otherPURE UUID: 94a4dac0-632e-45ff-ad58-d66f05ee0047
dc.identifier.otherPubMed: 27077369
dc.identifier.otherScopus: 84964344741
dc.identifier.otherPubMed: 27077369
dc.identifier.otherPubMedCentral: PMC4831823
dc.identifier.otherORCID: /0000-0002-8091-1458/work/27201531
dc.identifier.otherWOS: 000374131700113
dc.identifier.urihttp://hdl.handle.net/10023/8617
dc.descriptionRTM is supported by a Wellcome Trust Intermediate Clinical Fellowship (Grant No: 098522).en
dc.description.abstractInhibin B has been identified as a potential marker of Sertoli cell function in males. The aim of this study is to produce a normative model of serum inhibin B in males from birth to seventeen years. We used a well-defined search strategy to identify studies containing data that can contribute to a larger approximation of the healthy population. We combined data from four published studies (n = 709) and derived an internally validated model with high goodness-of-fit and normally distributed residuals. Our results show that inhibin B increases following birth to a post-natal peak of 270 pg/mL (IQR 210–335 pg/mL) and then decreases during childhood followed by a rise at around 8 years, peaking at a mean 305 pg/mL (IQR 240–445 pg/mL) at around age 17. Following this peak there is a slow decline to the standard mature adult normal range of 170 pg/mL (IQR 125–215 pg/mL). This normative model suggests that 35% of the variation in Inhibin B levels in young males is due to age alone, provides an age-specific reference range for inhibin B in the young healthy male population, and will be a powerful tool in evaluating the potential of inhibin B as a marker of Sertoli cell function in pre-pubertal boys.
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofPLoS Oneen
dc.rights© 2016 Kelsey et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectBiomarkersen
dc.subjectBlood Chemical Analysisen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectHumansen
dc.subjectInfanten
dc.subjectInfant, Newbornen
dc.subjectInhibinsen
dc.subjectMaleen
dc.subjectReference Valuesen
dc.subjectJournal Articleen
dc.subjectResearch Support, Non-U.S. Gov'ten
dc.subjectRJ101 Child Health. Child health servicesen
dc.subjectNDASen
dc.subject.lccRJ101en
dc.titleA normative model of serum inhibin B in young malesen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Computer Scienceen
dc.contributor.institutionUniversity of St Andrews.Centre for Interdisciplinary Research in Computational Algebraen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0153843
dc.description.statusPeer revieweden


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