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A normative model of serum inhibin B in young males

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Kelsey_2016_SerumInhibinB_PLoSONE_CC.pdf (1.199Mb)
Date
14/04/2016
Author
Kelsey, Thomas William
Miles, Amy
Mitchell, Rod T.
Anderson, Richard
Wallace, W. Hamish B.
Keywords
Adolescent
Adult
Biomarkers
Blood Chemical Analysis
Child
Child, Preschool
Humans
Infant
Infant, Newborn
Inhibins
Male
Reference Values
Journal Article
Research Support, Non-U.S. Gov't
RJ101 Child Health. Child health services
NDAS
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Abstract
Inhibin B has been identified as a potential marker of Sertoli cell function in males. The aim of this study is to produce a normative model of serum inhibin B in males from birth to seventeen years. We used a well-defined search strategy to identify studies containing data that can contribute to a larger approximation of the healthy population. We combined data from four published studies (n = 709) and derived an internally validated model with high goodness-of-fit and normally distributed residuals. Our results show that inhibin B increases following birth to a post-natal peak of 270 pg/mL (IQR 210–335 pg/mL) and then decreases during childhood followed by a rise at around 8 years, peaking at a mean 305 pg/mL (IQR 240–445 pg/mL) at around age 17. Following this peak there is a slow decline to the standard mature adult normal range of 170 pg/mL (IQR 125–215 pg/mL). This normative model suggests that 35% of the variation in Inhibin B levels in young males is due to age alone, provides an age-specific reference range for inhibin B in the young healthy male population, and will be a powerful tool in evaluating the potential of inhibin B as a marker of Sertoli cell function in pre-pubertal boys.
Citation
Kelsey , T W , Miles , A , Mitchell , R T , Anderson , R & Wallace , W H B 2016 , ' A normative model of serum inhibin B in young males ' , PLoS One , vol. 11 , no. 4 , e0153843 . https://doi.org/10.1371/journal.pone.0153843
Publication
PLoS One
Status
Peer reviewed
DOI
https://doi.org/10.1371/journal.pone.0153843
ISSN
1932-6203
Type
Journal article
Rights
© 2016 Kelsey et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Description
RTM is supported by a Wellcome Trust Intermediate Clinical Fellowship (Grant No: 098522).
Collections
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/8617

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