PCNA-binding proteins in the archaea : novel functionality beyond the conserved core
MetadataShow full item record
Sliding clamps play an essential role in coordinating protein activity in DNA metabolism in all three domains of life. In eukaryotes and archaea the sliding clamp is PCNA (proliferating cell nuclear antigen). Across the diversity of the archaea PCNA interacts with a highly conserved set of proteins with key roles in DNA replication and repair, including DNA polymerases B and D, replication factor C, the Fen1 nuclease and RNAseH2, but this core set of factors is likely to represent a fraction of the PCNA interactome only. Here I review three recently characterised non-core archaeal PCNA binding proteins NusS, NreA/NreB and TIP, highlighting what is known of their interactions with PCNA and their functions in vivo and in vitro. Gaining a detailed understanding of the non-core PCNA interactome will provide significant insights into key aspects of chromosome biology in divergent archaeal lineages.
MacNeill , S A 2016 , ' PCNA-binding proteins in the archaea : novel functionality beyond the conserved core ' Current Genetics , vol. 62 , no. 3 , pp. 527-532 . DOI: 10.1007/s00294-016-0577-3
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.