The Suzuki-Miyaura reaction performed using a palladium-N-Heterocyclic carbene catalyst and a weak inorganic base
Abstract
N-Heterocyclic carbenes (NHCs) have been shown to be useful ligands for the Suzuki-Miyaura cross-coupling at low catalyst loadings. We now report that the commercially available and air-stable [Pd(IPr)(cin)Cl] pre-catalyst permits the formation of various functionalized biaryls from aryl chlorides and boronic acids (37 examples) under very mild conditions using a mixture of ethanol/water as solvent and an inorganic base.
Citation
Izquierdo , F , Corpet , M M A E & Nolan , S P 2015 , ' The Suzuki-Miyaura reaction performed using a palladium-N-Heterocyclic carbene catalyst and a weak inorganic base ' , European Journal of Organic Chemistry , pp. 1920-1924 . https://doi.org/10.1002/ejoc.201500043
Publication
European Journal of Organic Chemistry
Status
Peer reviewed
ISSN
1434-193XType
Journal article
Description
We gratefully acknowledge the EC for funding through the seventh framework program SYNFLOW, the ERC (Advanced Investigator Award ‘FUNCAT’ to SPN) and the EPSRC. S.P.N. is a Royal Society Wolfson Research Merit Award holder.Collections
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