Efficient synthesis of novel chalcogen-containing derivatives of DNA nucleobases

Hua, Guoxiong; Du, Junyi; Cordes, David Bradford; Slawin, Alexandra Martha Zoya; Woollins, J Derek

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dc.contributor.author	Hua, Guoxiong
dc.contributor.author	Du, Junyi
dc.contributor.author	Cordes, David Bradford
dc.contributor.author	Slawin, Alexandra Martha Zoya
dc.contributor.author	Woollins, J Derek
dc.date.accessioned	2016-02-07T00:12:40Z
dc.date.available	2016-02-07T00:12:40Z
dc.date.issued	2015-03-25
dc.identifier.citation	Hua , G , Du , J , Cordes , D B , Slawin , A M Z & Woollins , J D 2015 , ' Efficient synthesis of novel chalcogen-containing derivatives of DNA nucleobases ' , Tetrahedron , vol. 71 , no. 12 , pp. 1792-1798 . https://doi.org/10.1016/j.tet.2015.02.005	en
dc.identifier.issn	0040-4020
dc.identifier.other	PURE: 166276665
dc.identifier.other	PURE UUID: 6c9c53d0-1d67-4de4-9bc5-34ea424f7c35
dc.identifier.other	WOS: 000350835800003
dc.identifier.other	Scopus: 84923552446
dc.identifier.other	ORCID: /0000-0002-5366-9168/work/28024006
dc.identifier.other	ORCID: /0000-0002-9527-6418/work/56861780
dc.identifier.other	ORCID: /0000-0002-1498-9652/work/31779181
dc.identifier.uri	https://hdl.handle.net/10023/8167
dc.description.abstract	The formation of a library of chalcogen-containing DNA nucleobase derivatives is presented. Reacting easily accessible 9-(2-bromoethyl)adenine with chalcogen-containing nucleophilic reagents led to a series of novel heteroatom derivatives incorporating S, Se and Te atoms prepared in satisfactory yields. Two representative X-ray structures are reported
dc.language.iso	eng
dc.relation.ispartof	Tetrahedron	en
dc.rights	2015 Elsevier Ltd. All rights reserved. This is the author’s version of a work that was accepted for publication in Tetrahedron. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron, 2015, DOI: http://dx.doi.org/10.1016/j.tet.2015.02.005	en
dc.subject	DNA nucleobases	en
dc.subject	9-(2-Bromoethyl)adenine	en
dc.subject	Adenine derivatives	en
dc.subject	Chalcogens	en
dc.subject	Woollins’ reagent	en
dc.subject	QD Chemistry	en
dc.subject	DAS	en
dc.subject.lcc	QD	en
dc.title	Efficient synthesis of novel chalcogen-containing derivatives of DNA nucleobases	en
dc.type	Journal article	en
dc.contributor.sponsor	EPSRC	en
dc.contributor.sponsor	EPSRC	en
dc.contributor.sponsor	EPSRC	en
dc.description.version	Postprint	en
dc.contributor.institution	University of St Andrews. School of Chemistry	en
dc.contributor.institution	University of St Andrews. Office of the Principal	en
dc.contributor.institution	University of St Andrews. EaSTCHEM	en
dc.identifier.doi	https://doi.org/10.1016/j.tet.2015.02.005
dc.description.status	Non peer reviewed	en
dc.date.embargoedUntil	2016-02-07
dc.identifier.url	http://www.sciencedirect.com/science/article/pii/S0040402015001398#appd001	en
dc.identifier.grantnumber	EP/K503940/1	en
dc.identifier.grantnumber	EP/K031252/1	en
dc.identifier.grantnumber	EP/K039210/1	en

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University of St Andrews Research

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