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Efficient synthesis of novel chalcogen-containing derivatives of DNA nucleobases

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dc.contributor.authorHua, Guoxiong
dc.contributor.authorDu, Junyi
dc.contributor.authorCordes, David Bradford
dc.contributor.authorSlawin, Alexandra Martha Zoya
dc.contributor.authorWoollins, J Derek
dc.date.accessioned2016-02-07T00:12:40Z
dc.date.available2016-02-07T00:12:40Z
dc.date.issued2015-03-25
dc.identifier166276665
dc.identifier6c9c53d0-1d67-4de4-9bc5-34ea424f7c35
dc.identifier000350835800003
dc.identifier84923552446
dc.identifier.citationHua , G , Du , J , Cordes , D B , Slawin , A M Z & Woollins , J D 2015 , ' Efficient synthesis of novel chalcogen-containing derivatives of DNA nucleobases ' , Tetrahedron , vol. 71 , no. 12 , pp. 1792-1798 . https://doi.org/10.1016/j.tet.2015.02.005en
dc.identifier.issn0040-4020
dc.identifier.otherORCID: /0000-0002-5366-9168/work/28024006
dc.identifier.otherORCID: /0000-0002-9527-6418/work/56861780
dc.identifier.otherORCID: /0000-0002-1498-9652/work/31779181
dc.identifier.urihttps://hdl.handle.net/10023/8167
dc.description.abstractThe formation of a library of chalcogen-containing DNA nucleobase derivatives is presented. Reacting easily accessible 9-(2-bromoethyl)adenine with chalcogen-containing nucleophilic reagents led to a series of novel heteroatom derivatives incorporating S, Se and Te atoms prepared in satisfactory yields. Two representative X-ray structures are reported
dc.format.extent567121
dc.language.isoeng
dc.relation.ispartofTetrahedronen
dc.subjectDNA nucleobasesen
dc.subject9-(2-Bromoethyl)adenineen
dc.subjectAdenine derivativesen
dc.subjectChalcogensen
dc.subjectWoollins’ reagenten
dc.subjectQD Chemistryen
dc.subjectDASen
dc.subject.lccQDen
dc.titleEfficient synthesis of novel chalcogen-containing derivatives of DNA nucleobasesen
dc.typeJournal articleen
dc.contributor.sponsorEPSRCen
dc.contributor.sponsorEPSRCen
dc.contributor.sponsorEPSRCen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. Office of the Principalen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doi10.1016/j.tet.2015.02.005
dc.description.statusNon peer revieweden
dc.date.embargoedUntil2016-02-07
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0040402015001398#appd001en
dc.identifier.grantnumberEP/K503940/1en
dc.identifier.grantnumberEP/K031252/1en
dc.identifier.grantnumberEP/K039210/1en


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