Efficient synthesis of novel chalcogen-containing derivatives of DNA nucleobases
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The formation of a library of chalcogen-containing DNA nucleobase derivatives is presented. Reacting easily accessible 9-(2-bromoethyl)adenine with chalcogen-containing nucleophilic reagents led to a series of novel heteroatom derivatives incorporating S, Se and Te atoms prepared in satisfactory yields. Two representative X-ray structures are reported
Hua , G , Du , J , Cordes , D B , Slawin , A M Z & Woollins , J D 2015 , ' Efficient synthesis of novel chalcogen-containing derivatives of DNA nucleobases ' Tetrahedron , vol 71 , no. 12 , pp. 1792-1798 . DOI: 10.1016/j.tet.2015.02.005
Non peer reviewed
2015 Elsevier Ltd. All rights reserved. This is the author’s version of a work that was accepted for publication in Tetrahedron. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron, 2015, DOI: http://dx.doi.org/10.1016/j.tet.2015.02.005
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