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General and mild Ni0-catalyzed α-arylation of ketones using aryl chlorides
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dc.contributor.author | Fernandez Salas, Jose Antonio | |
dc.contributor.author | Marelli, Enrico | |
dc.contributor.author | Cordes, David Bradford | |
dc.contributor.author | Slawin, Alexandra Martha Zoya | |
dc.contributor.author | Nolan, Steven Patrick | |
dc.date.accessioned | 2016-01-21T00:12:14Z | |
dc.date.available | 2016-01-21T00:12:14Z | |
dc.date.issued | 2015-03-02 | |
dc.identifier.citation | Fernandez Salas , J A , Marelli , E , Cordes , D B , Slawin , A M Z & Nolan , S P 2015 , ' General and mild Ni 0 -catalyzed α-arylation of ketones using aryl chlorides ' , Chemistry - A European Journal , vol. 21 , no. 10 , pp. 3906-3909 . https://doi.org/10.1002/chem.201406457 | en |
dc.identifier.issn | 0947-6539 | |
dc.identifier.other | PURE: 159994700 | |
dc.identifier.other | PURE UUID: 20c287da-148c-4dc4-816b-9846c2d797da | |
dc.identifier.other | WOS: 000350762400008 | |
dc.identifier.other | PubMed: 25611197 | |
dc.identifier.other | Scopus: 84943253345 | |
dc.identifier.other | ORCID: /0000-0002-5366-9168/work/28024009 | |
dc.identifier.other | ORCID: /0000-0002-9527-6418/work/56861620 | |
dc.identifier.uri | https://hdl.handle.net/10023/8048 | |
dc.description | The authors thank the ERC (Advanced Researcher award-FUNCAT), 7th Framework Program NMP2-LA-2010-246461 (SYNFLOW), the EPSRC and King Saud University for funding. | en |
dc.description.abstract | A general methodology for the α-arylation of ketones using a nickel catalyst has been developed. The new well-defined [Ni(IPr*)(cin)Cl] (1c) pre-catalyst showed great efficiency for this transformation, allowing the coupling of a wide range of ketones, including acetophenone derivatives, with various functionalised aryl chlorides. This cinnamyl-based Ni(NHC) complex has demonstrated a different behaviour to previously reported NHC-Ni catalysts. Preliminary mechanistic studies suggest a Ni0/NiII catalytic cycle to be at play. | |
dc.format.extent | 5 | |
dc.language.iso | eng | |
dc.relation.ispartof | Chemistry - A European Journal | en |
dc.rights | © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the accepted version of the following article: Fernández-Salas, J. A., Marelli, E., Cordes, D. B., Slawin, A. M. Z. and Nolan, S. P. (2015), General and Mild Ni0-Catalyzed α-Arylation of Ketones Using Aryl Chlorides. Chem. Eur. J., 21: 3906–3909, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/chem.201406457/abstract | en |
dc.subject | Aryl chlorides | en |
dc.subject | Cross-coupling reactions | en |
dc.subject | Ketone arylation | en |
dc.subject | N-heterocyclic carbenes | en |
dc.subject | Nickel | en |
dc.subject | Synthetic methods | en |
dc.subject | QD Chemistry | en |
dc.subject | NDAS | en |
dc.subject.lcc | QD | en |
dc.title | General and mild Ni0-catalyzed α-arylation of ketones using aryl chlorides | en |
dc.type | Journal article | en |
dc.contributor.sponsor | European Research Council | en |
dc.contributor.sponsor | European Research Council | en |
dc.contributor.sponsor | European Commission | en |
dc.contributor.sponsor | European Commission | en |
dc.contributor.sponsor | EPSRC | en |
dc.description.version | Postprint | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | https://doi.org/10.1002/chem.201406457 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2016-01-21 | |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/chem.201406457/suppinfo | en |
dc.identifier.grantnumber | FP7-227817 FUNCAT | en |
dc.identifier.grantnumber | FP7-227817 FUNCAT | en |
dc.identifier.grantnumber | 246461 | en |
dc.identifier.grantnumber | 246461 | en |
dc.identifier.grantnumber | EP/K039210/1 | en |
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