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dc.contributor.authorFernandez Salas, Jose Antonio
dc.contributor.authorMarelli, Enrico
dc.contributor.authorCordes, David Bradford
dc.contributor.authorSlawin, Alexandra Martha Zoya
dc.contributor.authorNolan, Steven Patrick
dc.date.accessioned2016-01-21T00:12:14Z
dc.date.available2016-01-21T00:12:14Z
dc.date.issued2015-03-02
dc.identifier.citationFernandez Salas , J A , Marelli , E , Cordes , D B , Slawin , A M Z & Nolan , S P 2015 , ' General and mild Ni 0 -catalyzed α-arylation of ketones using aryl chlorides ' , Chemistry - A European Journal , vol. 21 , no. 10 , pp. 3906-3909 . https://doi.org/10.1002/chem.201406457en
dc.identifier.issn0947-6539
dc.identifier.otherPURE: 159994700
dc.identifier.otherPURE UUID: 20c287da-148c-4dc4-816b-9846c2d797da
dc.identifier.otherWOS: 000350762400008
dc.identifier.otherPubMed: 25611197
dc.identifier.otherScopus: 84943253345
dc.identifier.otherORCID: /0000-0002-5366-9168/work/28024009
dc.identifier.otherORCID: /0000-0002-9527-6418/work/56861620
dc.identifier.urihttps://hdl.handle.net/10023/8048
dc.descriptionThe authors thank the ERC (Advanced Researcher award-FUNCAT), 7th Framework Program NMP2-LA-2010-246461 (SYNFLOW), the EPSRC and King Saud University for funding.en
dc.description.abstractA general methodology for the α-arylation of ketones using a nickel catalyst has been developed. The new well-defined [Ni(IPr*)(cin)Cl] (1c) pre-catalyst showed great efficiency for this transformation, allowing the coupling of a wide range of ketones, including acetophenone derivatives, with various functionalised aryl chlorides. This cinnamyl-based Ni(NHC) complex has demonstrated a different behaviour to previously reported NHC-Ni catalysts. Preliminary mechanistic studies suggest a Ni0/NiII catalytic cycle to be at play.
dc.format.extent5
dc.language.isoeng
dc.relation.ispartofChemistry - A European Journalen
dc.rights© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the accepted version of the following article: Fernández-Salas, J. A., Marelli, E., Cordes, D. B., Slawin, A. M. Z. and Nolan, S. P. (2015), General and Mild Ni0-Catalyzed α-Arylation of Ketones Using Aryl Chlorides. Chem. Eur. J., 21: 3906–3909, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/chem.201406457/abstracten
dc.subjectAryl chloridesen
dc.subjectCross-coupling reactionsen
dc.subjectKetone arylationen
dc.subjectN-heterocyclic carbenesen
dc.subjectNickelen
dc.subjectSynthetic methodsen
dc.subjectQD Chemistryen
dc.subjectNDASen
dc.subject.lccQDen
dc.titleGeneral and mild Ni0-catalyzed α-arylation of ketones using aryl chloridesen
dc.typeJournal articleen
dc.contributor.sponsorEuropean Research Councilen
dc.contributor.sponsorEuropean Research Councilen
dc.contributor.sponsorEuropean Commissionen
dc.contributor.sponsorEuropean Commissionen
dc.contributor.sponsorEPSRCen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doihttps://doi.org/10.1002/chem.201406457
dc.description.statusPeer revieweden
dc.date.embargoedUntil2016-01-21
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/chem.201406457/suppinfoen
dc.identifier.grantnumberFP7-227817 FUNCATen
dc.identifier.grantnumberFP7-227817 FUNCATen
dc.identifier.grantnumber246461en
dc.identifier.grantnumber246461en
dc.identifier.grantnumberEP/K039210/1en


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