General and mild Ni0-catalyzed α-arylation of ketones using aryl chlorides
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A general methodology for the α-arylation of ketones using a nickel catalyst has been developed. The new well-defined [Ni(IPr*)(cin)Cl] (1c) pre-catalyst showed great efficiency for this transformation, allowing the coupling of a wide range of ketones, including acetophenone derivatives, with various functionalised aryl chlorides. This cinnamyl-based Ni(NHC) complex has demonstrated a different behaviour to previously reported NHC-Ni catalysts. Preliminary mechanistic studies suggest a Ni0/NiII catalytic cycle to be at play.
Fernandez Salas , J A , Marelli , E , Cordes , D B , Slawin , A M Z & Nolan , S P 2015 , ' General and mild Ni 0 -catalyzed α-arylation of ketones using aryl chlorides ' Chemistry - A European Journal , vol 21 , no. 10 , pp. 3906-3909 . DOI: 10.1002/chem.201406457
Chemistry - A European Journal
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the accepted version of the following article: Fernández-Salas, J. A., Marelli, E., Cordes, D. B., Slawin, A. M. Z. and Nolan, S. P. (2015), General and Mild Ni0-Catalyzed α-Arylation of Ketones Using Aryl Chlorides. Chem. Eur. J., 21: 3906–3909, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/chem.201406457/abstract
The authors thank the ERC (Advanced Researcher award-FUNCAT), 7th Framework Program NMP2-LA-2010-246461 (SYNFLOW), the EPSRC and King Saud University for funding.
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