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dc.contributor.authorBautista-Aguilera, O.M.
dc.contributor.authorSamadi, A.
dc.contributor.authorChioua, M.
dc.contributor.authorNikolic, K.
dc.contributor.authorFilipic, S.
dc.contributor.authorAgbaba, D.
dc.contributor.authorSoriano, E.
dc.contributor.authorDe Andrés, L.
dc.contributor.authorRodríguez-Franco, M.I.
dc.contributor.authorAlcaro, S.
dc.contributor.authorRamsay, R.R.
dc.contributor.authorOrtuso, F.
dc.contributor.authorYañez, M.
dc.contributor.authorMarco-Contelles, J.
dc.date.accessioned2016-01-05T10:06:48Z
dc.date.available2016-01-05T10:06:48Z
dc.date.issued2014-12-26
dc.identifier.citationBautista-Aguilera , O M , Samadi , A , Chioua , M , Nikolic , K , Filipic , S , Agbaba , D , Soriano , E , De Andrés , L , Rodríguez-Franco , M I , Alcaro , S , Ramsay , R R , Ortuso , F , Yañez , M & Marco-Contelles , J 2014 , ' N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor ' , Journal of Medicinal Chemistry , vol. 57 , no. 24 , pp. 10455-10463 . https://doi.org/10.1021/jm501501aen
dc.identifier.issn0022-2623
dc.identifier.otherPURE: 163424658
dc.identifier.otherPURE UUID: 6cef75c9-097b-4287-84b2-d432d878cfef
dc.identifier.otherScopus: 84920175684
dc.identifier.otherWOS: 000347437400018
dc.identifier.otherORCID: /0000-0003-1535-4904/work/34907348
dc.identifier.urihttps://hdl.handle.net/10023/7954
dc.description.abstractOn the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofJournal of Medicinal Chemistryen
dc.rights© 2014. American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Medicinal Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/jm501501aen
dc.subjectDrug designen
dc.subjectQSARen
dc.subjectSynthesisen
dc.subjectBiological evaluationen
dc.subjectMultipotent modelsen
dc.subjectQD Chemistryen
dc.subject.lccQDen
dc.titleN-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitoren
dc.typeJournal articleen
dc.description.versionPostprinten
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1021/jm501501a
dc.description.statusPeer revieweden
dc.date.embargoedUntil2015-12-26
dc.identifier.urlhttp://pubs.acs.org/doi/suppl/10.1021/jm501501aen


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