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N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor
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dc.contributor.author | Bautista-Aguilera, O.M. | |
dc.contributor.author | Samadi, A. | |
dc.contributor.author | Chioua, M. | |
dc.contributor.author | Nikolic, K. | |
dc.contributor.author | Filipic, S. | |
dc.contributor.author | Agbaba, D. | |
dc.contributor.author | Soriano, E. | |
dc.contributor.author | De Andrés, L. | |
dc.contributor.author | Rodríguez-Franco, M.I. | |
dc.contributor.author | Alcaro, S. | |
dc.contributor.author | Ramsay, R.R. | |
dc.contributor.author | Ortuso, F. | |
dc.contributor.author | Yañez, M. | |
dc.contributor.author | Marco-Contelles, J. | |
dc.date.accessioned | 2016-01-05T10:06:48Z | |
dc.date.available | 2016-01-05T10:06:48Z | |
dc.date.issued | 2014-12-26 | |
dc.identifier.citation | Bautista-Aguilera , O M , Samadi , A , Chioua , M , Nikolic , K , Filipic , S , Agbaba , D , Soriano , E , De Andrés , L , Rodríguez-Franco , M I , Alcaro , S , Ramsay , R R , Ortuso , F , Yañez , M & Marco-Contelles , J 2014 , ' N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor ' , Journal of Medicinal Chemistry , vol. 57 , no. 24 , pp. 10455-10463 . https://doi.org/10.1021/jm501501a | en |
dc.identifier.issn | 0022-2623 | |
dc.identifier.other | PURE: 163424658 | |
dc.identifier.other | PURE UUID: 6cef75c9-097b-4287-84b2-d432d878cfef | |
dc.identifier.other | Scopus: 84920175684 | |
dc.identifier.other | WOS: 000347437400018 | |
dc.identifier.other | ORCID: /0000-0003-1535-4904/work/34907348 | |
dc.identifier.uri | https://hdl.handle.net/10023/7954 | |
dc.description.abstract | On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor. | |
dc.format.extent | 9 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Medicinal Chemistry | en |
dc.rights | © 2014. American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Medicinal Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/jm501501a | en |
dc.subject | Drug design | en |
dc.subject | QSAR | en |
dc.subject | Synthesis | en |
dc.subject | Biological evaluation | en |
dc.subject | Multipotent models | en |
dc.subject | QD Chemistry | en |
dc.subject.lcc | QD | en |
dc.title | N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor | en |
dc.type | Journal article | en |
dc.description.version | Postprint | en |
dc.description.version | Postprint | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1021/jm501501a | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2015-12-26 | |
dc.identifier.url | http://pubs.acs.org/doi/suppl/10.1021/jm501501a | en |
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