N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor
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Date
26/12/2014Metadata
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Abstract
On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.
Citation
Bautista-Aguilera , O M , Samadi , A , Chioua , M , Nikolic , K , Filipic , S , Agbaba , D , Soriano , E , De Andrés , L , Rodríguez-Franco , M I , Alcaro , S , Ramsay , R R , Ortuso , F , Yañez , M & Marco-Contelles , J 2014 , ' N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor ' , Journal of Medicinal Chemistry , vol. 57 , no. 24 , pp. 10455-10463 . https://doi.org/10.1021/jm501501a
Publication
Journal of Medicinal Chemistry
Status
Peer reviewed
ISSN
0022-2623Type
Journal article
Rights
© 2014. American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Medicinal Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/jm501501a
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