Exploring the scope of the isothiourea-mediated synthesis of dihydropyridinones
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Date
21/02/2015Author
Grant ID
EP/J018139/1
EP/J018139/1
EP/K039210/1
N/A
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The exploration and expansion of the scope of the isothiourea-mediated synthesis of dihydropyridinones is presented. The use of ketimines derived from α,β-unsaturated γ-ketoesters as the Michael acceptor in a Michael addition / lactamisation cascade gives access to a range of dihydropyridinones with high enantioselectivity. The nature of the N-sulfonyl group present on the ketimine is extensively investigated, with further studies into derivatisation of the dihydropyridinone core also reported.
Citation
Yeh , P-P , Daniels , D S B , Fallan , C , Gould , E R , Simal Fernandez , C , Taylor , J E , Slawin , A M Z & Smith , A D 2015 , ' Exploring the scope of the isothiourea-mediated synthesis of dihydropyridinones ' , Organic & Biomolecular Chemistry , vol. 13 , no. 7 , pp. 2177-2191 . https://doi.org/10.1039/c4ob02408g
Publication
Organic & Biomolecular Chemistry
Status
Peer reviewed
ISSN
1477-0520Type
Journal article
Description
The authors thank the Royal Society for a University Research Fellowship (ADS), the EU (IEF for CS) and the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) ERC Grant Agreement No. 279850 (JET and CF) and the EPSRC grant numbers EP/J018139/1 (DSBD) and EP/K00445X/1 (EG) for funding.Collections
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