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Palladium-catalyzed α-arylation of arylketones at low catalyst loadings

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dc.contributor.authorMarelli, Enrico
dc.contributor.authorCorpet, Martin Michel Alfred Eton
dc.contributor.authorDavies, Sian
dc.contributor.authorNolan, Steven Patrick
dc.date.accessioned2015-11-20T00:11:39Z
dc.date.available2015-11-20T00:11:39Z
dc.date.issued2014-12-22
dc.identifier.citationMarelli , E , Corpet , M M A E , Davies , S & Nolan , S P 2014 , ' Palladium-catalyzed α-arylation of arylketones at low catalyst loadings ' , Chemistry - A European Journal , vol. 20 , no. 52 , pp. 17272-17276 . https://doi.org/10.1002/chem.201404900en
dc.identifier.issn0947-6539
dc.identifier.otherPURE: 159993747
dc.identifier.otherPURE UUID: c10c2110-91bf-4973-be17-516924f9d8ed
dc.identifier.otherWOS: 000346468000002
dc.identifier.otherScopus: 84920123053
dc.identifier.urihttp://hdl.handle.net/10023/7824
dc.descriptionThe authors thank the ERC (Advanced Researcher award-FUNCAT), 7th Framework Program NMP2-LA-2010–246461 (SYNFLOW) and King Saud University for funding.en
dc.description.abstractA general catalytic protocol for the a-arylation of aryl ketones has been developed. It involves the use of a preformed, bench-stable Pd–N-heterocyclic carbene precatalyst bearing IHept as an ancillary ligand, and allows the coupling of various functionalized coupling partners at very low catalyst loading. Careful choice of the solvent/base system was crucial to obtain optimum catalyst performance. The pre-catalyst was also successfully tested in the synthesis of an industrially relevant compound.
dc.format.extent5
dc.language.isoeng
dc.relation.ispartofChemistry - A European Journalen
dc.rights© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the accepted version of the following article: Marelli, E., Corpet, M., Davies, S. R. and Nolan, S. P. (2014), Palladium-Catalyzed α-Arylation of Arylketones at Low Catalyst Loadings. Chem. Eur. J., 20: 17272–17276, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/chem.201404900/abstracten
dc.subjectCatalystsen
dc.subjectKetone arylationen
dc.subjectMonodentate ligandsen
dc.subjectNHCen
dc.subjectPalladiumen
dc.subjectQD Chemistryen
dc.subject.lccQDen
dc.titlePalladium-catalyzed α-arylation of arylketones at low catalyst loadingsen
dc.typeJournal articleen
dc.contributor.sponsorEuropean Research Councilen
dc.contributor.sponsorEuropean Commissionen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doihttps://doi.org/10.1002/chem.201404900
dc.description.statusPeer revieweden
dc.date.embargoedUntil2015-11-20
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/chem.201404900/suppinfoen
dc.identifier.grantnumberFP7-227817 FUNCATen
dc.identifier.grantnumber246461en


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