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Palladium-catalyzed α-arylation of arylketones at low catalyst loadings

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Nolan_2015_Chem_Ketone_AM.pdf (540.0Kb)
Date
22/12/2014
Author
Marelli, Enrico
Corpet, Martin Michel Alfred Eton
Davies, Sian
Nolan, Steven Patrick
Keywords
Catalysts
Ketone arylation
Monodentate ligands
NHC
Palladium
QD Chemistry
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Abstract
A general catalytic protocol for the a-arylation of aryl ketones has been developed. It involves the use of a preformed, bench-stable Pd–N-heterocyclic carbene precatalyst bearing IHept as an ancillary ligand, and allows the coupling of various functionalized coupling partners at very low catalyst loading. Careful choice of the solvent/base system was crucial to obtain optimum catalyst performance. The pre-catalyst was also successfully tested in the synthesis of an industrially relevant compound.
Citation
Marelli , E , Corpet , M M A E , Davies , S & Nolan , S P 2014 , ' Palladium-catalyzed α-arylation of arylketones at low catalyst loadings ' , Chemistry - A European Journal , vol. 20 , no. 52 , pp. 17272-17276 . https://doi.org/10.1002/chem.201404900
Publication
Chemistry - A European Journal
Status
Peer reviewed
DOI
https://doi.org/10.1002/chem.201404900
ISSN
0947-6539
Type
Journal article
Rights
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the accepted version of the following article: Marelli, E., Corpet, M., Davies, S. R. and Nolan, S. P. (2014), Palladium-Catalyzed α-Arylation of Arylketones at Low Catalyst Loadings. Chem. Eur. J., 20: 17272–17276, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/chem.201404900/abstract
Description
The authors thank the ERC (Advanced Researcher award-FUNCAT), 7th Framework Program NMP2-LA-2010–246461 (SYNFLOW) and King Saud University for funding.
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  • University of St Andrews Research
URL
http://onlinelibrary.wiley.com/doi/10.1002/chem.201404900/suppinfo
URI
http://hdl.handle.net/10023/7824

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