N-Heterocyclic carbene copper(I) catalysed N-methylation of amines using CO2
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The N-methylation of amines using CO2 and PhSiH3 as source of CH3 was efficiently performed using a N-heterocyclic carbene copper(I) complex. The methodology was found compatible with aromatic and aliphatic primary and secondary amines. Synthetic and computational studies have been carried out to support the proposed reaction mechanism for this transformation.
Santoro , O , Lazreg , F , Minenkov , Y , Cavallo , L & Cazin , C S J 2015 , ' N -Heterocyclic carbene copper(I) catalysed N -methylation of amines using CO 2 ' Dalton Transactions , vol 44 , no. 41 , pp. 18138-18144 . DOI: 10.1039/C5DT03506F
Copyright 2015 the Authors. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/).
The authors gratefully acknowledge the Royal Society (University Research Fellowship to C.S.J.C.), the EPSRC (DTG011 EP/J500549/1) and the King Abdullah University of Science and Technology for funding, and the EPSRC National Mass Spectrometry Service Centre at Swansea University for HMRS analyses.