N-Heterocyclic carbene copper(I) catalysed N-methylation of amines using CO2
Abstract
The N-methylation of amines using CO2 and PhSiH3 as source of CH3 was efficiently performed using a N-heterocyclic carbene copper(I) complex. The methodology was found compatible with aromatic and aliphatic primary and secondary amines. Synthetic and computational studies have been carried out to support the proposed reaction mechanism for this transformation.
Citation
Santoro , O , Lazreg , F , Minenkov , Y , Cavallo , L & Cazin , C S J 2015 , ' N -Heterocyclic carbene copper(I) catalysed N -methylation of amines using CO 2 ' , Dalton Transactions , vol. 44 , no. 41 , pp. 18138-18144 . https://doi.org/10.1039/C5DT03506F
Publication
Dalton Transactions
Status
Peer reviewed
ISSN
1477-9226Type
Journal article
Description
The authors gratefully acknowledge the Royal Society (University Research Fellowship to C.S.J.C.), the EPSRC (DTG011 EP/J500549/1) and the King Abdullah University of Science and Technology for funding, and the EPSRC National Mass Spectrometry Service Centre at Swansea University for HMRS analyses.Collections
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