Mathematical modeling of tumor growth and treatment
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Using mathematical models to simulate dynamic biological processes has a long history. Over the past couple of decades or so, quantitative approaches have also made their way into cancer research. An increasing number of mathematical, physical, computational and engineering techniques have been applied to various aspects of tumor growth, with the ultimate goal of understanding the response of the cancer population to clinical intervention. So-called in silico trials that predict patient-specific response to various dose schedules or treatment combinations and sequencing are on the way to becoming an invaluable tool to optimize patient care. Herein we describe fundamentals of mathematical modeling of tumor growth and tumor-host interactions, and summarize some of the seminal and most prominent approaches.
Enderling , H & Chaplain , M A J 2014 , ' Mathematical modeling of tumor growth and treatment ' Current Pharmaceutical Design , vol 20 , no. 30 , pp. 4934-4940 . DOI: 10.2174/1381612819666131125150434
Current Pharmaceutical Design
© 2014, Publisher / the Author(s). This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at www.euekaselect.com / https://dx.doi.org/10.2174/1381612819666131125150434