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dc.contributor.authorMattern, D.J.
dc.contributor.authorValiante, V.
dc.contributor.authorUnkles, S.E.
dc.contributor.authorBrakhage, A.A.
dc.date.accessioned2015-08-21T15:10:02Z
dc.date.available2015-08-21T15:10:02Z
dc.date.issued2015-07-30
dc.identifier.citationMattern , D J , Valiante , V , Unkles , S E & Brakhage , A A 2015 , ' Synthetic biology of fungal natural products ' , Frontiers in Microbiology , vol. 6 , 775 . https://doi.org/10.3389/fmicb.2015.00775en
dc.identifier.issn1664-302X
dc.identifier.otherPURE: 211293810
dc.identifier.otherPURE UUID: d24eced3-e5c1-4b87-8f11-75a89e9363df
dc.identifier.otherScopus: 84938836541
dc.identifier.otherWOS: 000358889200001
dc.identifier.urihttp://hdl.handle.net/10023/7304
dc.descriptionThis work was supported by the DFG-funded excellence graduate school Jena School for Microbial Communication (JSMC; DJM, AAB), the collaborative research center (SFB) 1127 Chemical Mediators in Complex Biosystems (ChemBioSys—AAB, project B02) and the Leibniz Research Cluster Biotechnology 2020+ (VV). Date of Acceptance: 14/07/2015en
dc.description.abstractSynthetic biology is an ever-expanding field in science, also encompassing the research area of fungal natural product (NP) discovery and production. Until now, different aspects of synthetic biology have been covered in fungal NP studies from the manipulation of different regulatory elements and heterologous expression of biosynthetic pathways to the engineering of different multidomain biosynthetic enzymes such as polyketide synthases or non-ribosomal peptide synthetases. The following review will cover some of the exemplary studies of synthetic biology in filamentous fungi showing the capacity of these eukaryotes to be used as model organisms in the field. From the vast array of different NPs produced to the ease for genetic manipulation, filamentous fungi have proven to be an invaluable source for the further development of synthetic biology tools.
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofFrontiers in Microbiologyen
dc.rights© 2015 Mattern, Valiante, Unkles and Brakhage. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.subjectSynthetic biologyen
dc.subjectFungal natural productsen
dc.subjectRegulation of natural productsen
dc.subjectHeterologous expressionen
dc.subjectEgineering of biosynthetic enzymesen
dc.subjectQR Microbiologyen
dc.subject.lccQRen
dc.titleSynthetic biology of fungal natural productsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.3389/fmicb.2015.00775
dc.description.statusPeer revieweden


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