Synthetic biology of fungal natural products
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Synthetic biology is an ever-expanding field in science, also encompassing the research area of fungal natural product (NP) discovery and production. Until now, different aspects of synthetic biology have been covered in fungal NP studies from the manipulation of different regulatory elements and heterologous expression of biosynthetic pathways to the engineering of different multidomain biosynthetic enzymes such as polyketide synthases or non-ribosomal peptide synthetases. The following review will cover some of the exemplary studies of synthetic biology in filamentous fungi showing the capacity of these eukaryotes to be used as model organisms in the field. From the vast array of different NPs produced to the ease for genetic manipulation, filamentous fungi have proven to be an invaluable source for the further development of synthetic biology tools.
Mattern , D J , Valiante , V , Unkles , S E & Brakhage , A A 2015 , ' Synthetic biology of fungal natural products ' Frontiers in Microbiology , vol 6 , 775 . DOI: 10.3389/fmicb.2015.00775
Frontiers in Microbiology
© 2015 Mattern, Valiante, Unkles and Brakhage. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
This work was supported by the DFG-funded excellence graduate school Jena School for Microbial Communication (JSMC; DJM, AAB), the collaborative research center (SFB) 1127 Chemical Mediators in Complex Biosystems (ChemBioSys—AAB, project B02) and the Leibniz Research Cluster Biotechnology 2020+ (VV). Date of Acceptance: 14/07/2015