Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp3)-H bonds
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The first nickel catalyzed deprotonative cross coupling between C(sp3)-H bonds and aryl chlorides is reported, allowing the challenging arylation of benzylimines in the absence of directing group or stoichiometric metal activation. This methodology represents a convenient access to the (diarylmethyl)amine moiety, which is widespread in pharmaceutically relevant compounds.
Fernandez Salas , J A , Marelli , E & Nolan , S P 2015 , ' Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp 3 )-H bonds ' Journal of Polymer Science Part A: Polymer Chemistry , vol 6 , no. 8 , pp. 4973-4977 . DOI: 10.1039/C5SC01589H
Journal of Polymer Science Part A: Polymer Chemistry
Copyright 2015 the Authors. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence (http://creativecommons.org/licenses/by-nc/3.0/).
DescriptionThe authors thank the ERC (Advanced Researcher award-FUNCAT), the EPSRC (grant no EP/J011053/1) and King Saud University for funding. SPN is a Royal Society Wolfson Research Merit Award holder.
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