Rapid Asymmetric Transfer Hydroformylation (ATHF) of disubstituted alkenes using paraformaldehyde as a syngas surrogate
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As an alternative to conventional asymmetric hydroformylation (AHF), Asymmetric Transfer Hydroformylation (ATHF) using formaldehyde as a surrogate for syngas is reported. A catalyst derived from commercially available [Rh(acac)(CO)2] and Ph-BPE stands out in terms of both activity and enantioselectivity. Remarkably, not only are high selectivities achievable, the reactions are very simple to carry out, and can give higher enantioselectivity (up to 96% e.e.) and/or turnover frequencies than those that are achievable using the same catalyst (or other leading catalysts) using typical conditions for AHF.
Fuentes García , J A , Pittaway , R & Clarke , M 2015 , ' Rapid Asymmetric Transfer Hydroformylation (ATHF) of disubstituted alkenes using paraformaldehyde as a syngas surrogate ' Chemistry - A European Journal , vol 21 , no. 30 , pp. 10645-10649 . DOI: 10.1002/chem.201502049
Chemistry - A European Journal
© 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
The authors thank Dr. Reddys (UK) and the Royal Society for an Industry Fellowship in the early stage of this work (2012–2014), and the EPSRC for funding (EP/M003868/1).
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