Hydrogenation of unactivated enamines to tertiary amines : rhodium complexes of fluorinated phosphines give marked improvements in catalytic activity
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In the hydrogenation of sluggish unactivated enamine substrates, Rh complexes of electron-deficient phosphines are demonstrated to be far more reactive catalysts than those derived from triphenylphosphine. These operate at low catalyst loadings (down to 0.01 mol %) and are able to reduce tetrasubstituted enamines. The use of the sustainable and environmentally benign solvent (R)-limonene for the reaction is also reported with the amine isolated by acid extraction.
Tin , S , Fanjul , T & Clarke , M L 2015 , ' Hydrogenation of unactivated enamines to tertiary amines : rhodium complexes of fluorinated phosphines give marked improvements in catalytic activity ' Beilstein Journal of Organic Chemistry , vol 11 , pp. 622-627 . DOI: 10.3762/bjoc.11.70
Beilstein Journal of Organic Chemistry
© 2015 Tin et al; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DescriptionDate of Acceptance: 16/04/2015
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