Show simple item record

Files in this item


Item metadata

dc.contributor.authorLohse, K.
dc.contributor.authorClarke, M.
dc.contributor.authorRitchie, M.G.
dc.contributor.authorEtges, W.J.
dc.identifier.citationLohse , K , Clarke , M , Ritchie , M G & Etges , W J 2015 , ' Genome-wide tests for introgression between cactophilic Drosophila implicate a role of inversions during speciation ' , Evolution , vol. 69 , no. 5 , pp. 1178-1190 .
dc.identifier.otherPURE: 188736314
dc.identifier.otherPURE UUID: 9bcb6993-1e4f-4137-ba71-a652951c607b
dc.identifier.otherScopus: 84929514813
dc.identifier.otherORCID: /0000-0001-7913-8675/work/46761124
dc.identifier.otherWOS: 000354561600006
dc.descriptionK.L. was funded by a junior research fellowship from the National Environmental Research Council, UK (NE/I020288/1, NBAF659).en
dc.description.abstractModels of speciation-with-gene-flow have shown that the reduction in recombination between alternative chromosome arrangements can facilitate the fixation of locally adaptive genes in the face of gene flow and contribute to speciation. However, it has proven frustratingly difficult to show empirically that inversions have reduced gene flow and arose during or shortly after the onset of species divergence rather than represent ancestral polymorphisms. Here, we present an analysis of whole genome data from a pair of cactophilic fruit flies, Drosophila mojavensis and D. arizonae, which are reproductively isolated in the wild and differ by several large inversions on three chromosomes. We found an increase in divergence at rearranged compared to colinear chromosomes. Using the density of divergent sites in short sequence blocks we fit a series of explicit models of species divergence in which gene flow is restricted to an initial period after divergence and may differ between colinear and rearranged parts of the genome. These analyses show that D. mojavensis and D. arizonae have experienced postdivergence gene flow that ceased around 270 KY ago and was significantly reduced in chromosomes with fixed inversions. Moreover, we show that these inversions most likely originated around the time of species divergence which is compatible with theoretical models that posit a role of inversions in speciation with gene flow.
dc.rights© 2015 The Author(s). Evolution published by Wiley Periodicals, Inc. on behalf of The Society for the Study of Evolution. This is an open access article under the terms of the Creative Commons Attribution License (, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectSpeciation with gene flowen
dc.subjectDivergence genomicsen
dc.subjectDrosophila mojavensisen
dc.subjectDrosophila arizonaeen
dc.subjectQH426 Geneticsen
dc.titleGenome-wide tests for introgression between cactophilic Drosophila implicate a role of inversions during speciationen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Centre for Biological Diversityen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.description.statusPeer revieweden

This item appears in the following Collection(s)

Show simple item record