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Genome-wide tests for introgression between cactophilic Drosophila implicate a role of inversions during speciation

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Ritchie_2015_Evo_Genome_CC.pdf (626.6Kb)
Date
05/2015
Author
Lohse, K.
Clarke, M.
Ritchie, M.G.
Etges, W.J.
Keywords
Speciation with gene flow
Inversions
Divergence genomics
Drosophila mojavensis
Drosophila arizonae
QH426 Genetics
DAS
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Abstract
Models of speciation-with-gene-flow have shown that the reduction in recombination between alternative chromosome arrangements can facilitate the fixation of locally adaptive genes in the face of gene flow and contribute to speciation. However, it has proven frustratingly difficult to show empirically that inversions have reduced gene flow and arose during or shortly after the onset of species divergence rather than represent ancestral polymorphisms. Here, we present an analysis of whole genome data from a pair of cactophilic fruit flies, Drosophila mojavensis and D. arizonae, which are reproductively isolated in the wild and differ by several large inversions on three chromosomes. We found an increase in divergence at rearranged compared to colinear chromosomes. Using the density of divergent sites in short sequence blocks we fit a series of explicit models of species divergence in which gene flow is restricted to an initial period after divergence and may differ between colinear and rearranged parts of the genome. These analyses show that D. mojavensis and D. arizonae have experienced postdivergence gene flow that ceased around 270 KY ago and was significantly reduced in chromosomes with fixed inversions. Moreover, we show that these inversions most likely originated around the time of species divergence which is compatible with theoretical models that posit a role of inversions in speciation with gene flow.
Citation
Lohse , K , Clarke , M , Ritchie , M G & Etges , W J 2015 , ' Genome-wide tests for introgression between cactophilic Drosophila implicate a role of inversions during speciation ' , Evolution , vol. 69 , no. 5 , pp. 1178-1190 . https://doi.org/10.1111/evo.12650
Publication
Evolution
Status
Peer reviewed
DOI
https://doi.org/10.1111/evo.12650
ISSN
0014-3820
Type
Journal article
Rights
© 2015 The Author(s). Evolution published by Wiley Periodicals, Inc. on behalf of The Society for the Study of Evolution. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Description
K.L. was funded by a junior research fellowship from the National Environmental Research Council, UK (NE/I020288/1, NBAF659).
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  • University of St Andrews Research
URL
http://onlinelibrary.wiley.com/doi/10.1111/evo.12650/suppinfo
URI
http://hdl.handle.net/10023/6667

Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

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