St Andrews Research Repository

St Andrews University Home
View Item 
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.

Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis

Thumbnail
View/Open
weinert2015ncomms6740.pdf (911.0Kb)
Date
05/2015
Author
Weinert, Lucy A
Chaudhuri, Roy R
Wang, Jinhong
Peters, Sarah E
Corander, Jukka
Jombart, Thibaut
Baig, Abiyad
Howell, Kate J
Vehkala, Minna
Välimäki, Niko
Harris, David
Chieu, Tran Thi Bich
Van Vinh Chau, Nguyen
Campbell, James
Schultsz, Constance
Parkhill, Julian
Bentley, Stephen D
Langford, Paul R
Rycroft, Andrew N
Wren, Brendan W
Farrar, Jeremy
Baker, Stephen
Hoa, Ngo Thi
Holden, Matthew T G
Tucker, Alexander W
Maskell, Duncan J
BRaDP1T Consortium
Keywords
R Medicine
DAS
SDG 3 - Good Health and Well-being
Metadata
Show full item record
Altmetrics Handle Statistics
Altmetrics DOI Statistics
Abstract
Streptococcus suis causes disease in pigs worldwide and is increasingly implicated in zoonotic disease in East and South-East Asia. To understand the genetic basis of disease in S. suis, we study the genomes of 375 isolates with detailed clinical phenotypes from pigs and humans from the United Kingdom and Vietnam. Here, we show that isolates associated with disease contain substantially fewer genes than non-clinical isolates, but are more likely to encode virulence factors. Human disease isolates are limited to a single-virulent population, originating in the 1920s when pig production was intensified, but no consistent genomic differences between pig and human isolates are observed. There is little geographical clustering of different S. suis subpopulations, and the bacterium undergoes high rates of recombination, implying that an increase in virulence anywhere in the world could have a global impact over a short timescale.
Citation
Weinert , L A , Chaudhuri , R R , Wang , J , Peters , S E , Corander , J , Jombart , T , Baig , A , Howell , K J , Vehkala , M , Välimäki , N , Harris , D , Chieu , T T B , Van Vinh Chau , N , Campbell , J , Schultsz , C , Parkhill , J , Bentley , S D , Langford , P R , Rycroft , A N , Wren , B W , Farrar , J , Baker , S , Hoa , N T , Holden , M T G , Tucker , A W , Maskell , D J & BRaDP1T Consortium 2015 , ' Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis ' , Nature Communications , vol. 6 , 6740 . https://doi.org/10.1038/ncomms7740
Publication
Nature Communications
Status
Peer reviewed
DOI
https://doi.org/10.1038/ncomms7740
ISSN
2041-1723
Type
Journal article
Rights
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Description
This work was supported by a Longer and Larger (LoLa) grant from the Biotechnology and Biological Sciences Research Council (grant numbers BB/G020744/1, BB/G019177/1, BB/G019274/1 and BB/G003203/1), the UK Department for Environment, Food and Rural Affairs and Zoetis, awarded to the Bacterial Respiratory Diseases of Pigs: 1 Technology (BRaDP1T) consortium. Part of this work was supported by The Wellcome Trust Overseas Programme in Vietnam (2010–2015) (089276/Z/09/Z) and the Vietnam Initiative on Zoonotic Infections (VIZIONS) award (WT/093724/Z/10/Z). S.D.B. is partly funded by the NIHR Cambridge BRC.
Collections
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/6458

Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

Advanced Search

Browse

All of RepositoryCommunities & CollectionsBy Issue DateNamesTitlesSubjectsClassificationTypeFunderThis CollectionBy Issue DateNamesTitlesSubjectsClassificationTypeFunder

My Account

Login

Open Access

To find out how you can benefit from open access to research, see our library web pages and Open Access blog. For open access help contact: openaccess@st-andrews.ac.uk.

Accessibility

Read our Accessibility statement.

How to submit research papers

The full text of research papers can be submitted to the repository via Pure, the University's research information system. For help see our guide: How to deposit in Pure.

Electronic thesis deposit

Help with deposit.

Repository help

For repository help contact: Digital-Repository@st-andrews.ac.uk.

Give Feedback

Cookie policy

This site may use cookies. Please see Terms and Conditions.

Usage statistics

COUNTER-compliant statistics on downloads from the repository are available from the IRUS-UK Service. Contact us for information.

© University of St Andrews Library

University of St Andrews is a charity registered in Scotland, No SC013532.

  • Facebook
  • Twitter