Now showing items 1-8 of 8

  • Building a genomic framework for prospective MRSA surveillance in the United Kingdom and the Republic of Ireland 

    Reuter, Sandra; Török, Estee M; Holden, Matthew Tg; Reynolds, Rosy; Raven, Kathy E; Blane, Beth; Donker, Tjibbe; Bentley, Stephen D; Aanensen, David M; Grundmann, Hajo; Feil, Edward J; Spratt, Brian G; Parkhill, Julian; Peacock, Sharon J (2016-02) - Journal article
    The correct interpretation of microbial sequencing data applied to surveillance and outbreak investigation depends on accessible genomic databases to provide vital genetic context. Our aim was to construct and describe a ...
  • Evolutionary dynamics of methicillin-resistant Staphylococcus aureus within a healthcare system 

    Hsu, Li-Yang; Harris, Simon R; Chlebowicz, Monika A; Lindsay, Jodi A; Koh, Tse-Hsien; Krishnan, Prabha; Tan, Thean-Yen; Hon, Pei-Yun; Grubb, Warren B; Bentley, Stephen D; Parkhill, Julian; Peacock, Sharon J; Holden, Matthew Tg (2015-04-23) - Journal article
    Background In the past decade, several countries have seen gradual replacement of endemic multi-resistant healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) with clones that are more susceptible to ...
  • Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis 

    Weinert, Lucy A; Chaudhuri, Roy R; Wang, Jinhong; Peters, Sarah E; Corander, Jukka; Jombart, Thibaut; Baig, Abiyad; Howell, Kate J; Vehkala, Minna; Välimäki, Niko; Harris, David; Chieu, Tran Thi Bich; Van Vinh Chau, Nguyen; Campbell, James; Schultsz, Constance; Parkhill, Julian; Bentley, Stephen D; Langford, Paul R; Rycroft, Andrew N; Wren, Brendan W; Farrar, Jeremy; Baker, Stephen; Hoa, Ngo Thi; Holden, Matthew T G; Tucker, Alexander W; Maskell, Duncan J; BRaDP1T Consortium (2015-05) - Journal article
    Streptococcus suis causes disease in pigs worldwide and is increasingly implicated in zoonotic disease in East and South-East Asia. To understand the genetic basis of disease in S. suis, we study the genomes of 375 isolates ...
  • Novel determinants of antibiotic resistance : identification of mutated loci in highly methicillin-resistant subpopulations of methicillin-resistant Staphylococcus aureus 

    Dordel, Janina; Kim, Choonkeun; Chung, Marilyn; Pardos de la Gándara, María; Holden, Matthew T J; Parkhill, Julian; de Lencastre, Hermínia; Bentley, Stephen D; Tomasz, Alexander (2014-04-08) - Journal article
    We identified mutated genes in highly resistant subpopulations of methicillin-resistant Staphylococcus aureus (MRSA) that are most likely responsible for the historic failure of the β-lactam family of antibiotics as ...
  • Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns 

    Donker, Tjibbe; Reuter, Sandra; Scriberras, James; Reynolds, Rosy; Brown, Nicholas M; Török, M Estée; James, Richard; Network, East Of England Microbiology Research; Aanensen, David M; Bentley, Stephen D; Holden, Matthew T. G.; Parkhill, Julian; Spratt, Brian G; Peacock, Sharon J; Feil, Edward J; Grundmann, Hajo (2017-07-09) - Journal article
    Antibiotic resistance forms a serious threat to the health of hospitalised patients, rendering otherwise treatable bacterial infections potentially life-threatening. A thorough understanding of the mechanisms by which ...
  • Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus 

    Steinig, Eike J; Andersson, Patiyan; Harris, Simon R; Sarovich, Derek S; Manoharan, Anand; Coupland, Paul; Holden, Matthew Tg; Parkhill, Julian; Bentley, Stephen D; Robinson, D Ashley; Tong, Steven Yc (2015-05-16) - Journal article
    Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-associated infection, but there is growing awareness of the emergence of multidrug-resistant lineages in community settings around the world. ...
  • Whole-genome sequencing reveals clonal expansion of multiresistant Staphylococcus haemolyticus in European hospitals 

    Cavanagh, Jorunn Pauline; Hjerde, Erik; Holden, Matthew T G; Kahlke, Tim; Klingenberg, Claus; Flægstad, Trond; Parkhill, Julian; Bentley, Stephen D; Sollid, Johanna U Ericson (2014-11-11) - Journal article
    Objectives Staphylococcus haemolyticus is an emerging cause of nosocomial infections, primarily affecting immunocompromised patients. A comparative genomic analysis was performed on clinical S. haemolyticus isolates to ...
  • Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis : a retrospective observational study 

    Bryant, Josephine M; Harris, Simon R; Parkhill, Julian; Dawson, Rodney; Diacon, Andreas; van Helden, Paul; Pym, Alex; Ahmad Mahayiddin, Aziah; Chuchottaworn, C; Sanne, Ian M; Louw, Cheryl; Boeree, Martin J; Hoelscher, Michael; McHugh, Timothy D; Bateson, Anna L C; Hunt, Robert D; Mwaigwisya, Solomon; Wright, Laura; Gillespie, Stephen Henry; Bentley, Stephen D (2013-12) - Journal article