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Development of a graded index microlens based fiber optical trap and its characterization using principal component analysis
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dc.contributor.author | Nylk, Jonathan | |
dc.contributor.author | Kristensen, M. V. G. | |
dc.contributor.author | Mazilu, Michael | |
dc.contributor.author | Kubasik-Thayil, Anisha | |
dc.contributor.author | Mitchell, C. A. | |
dc.contributor.author | Campbell, Elaine Catherine | |
dc.contributor.author | Powis, Simon John | |
dc.contributor.author | Gunn-Moore, Frank J | |
dc.contributor.author | Dholakia, Kishan | |
dc.date.accessioned | 2015-04-06T14:31:02Z | |
dc.date.available | 2015-04-06T14:31:02Z | |
dc.date.issued | 2015-04-01 | |
dc.identifier | 175276399 | |
dc.identifier | 9e9c0ea7-3162-46da-b47f-bd819798ac2a | |
dc.identifier | 84948771934 | |
dc.identifier | 000352228400036 | |
dc.identifier.citation | Nylk , J , Kristensen , M V G , Mazilu , M , Kubasik-Thayil , A , Mitchell , C A , Campbell , E C , Powis , S J , Gunn-Moore , F J & Dholakia , K 2015 , ' Development of a graded index microlens based fiber optical trap and its characterization using principal component analysis ' , Biomedical Optics Express , vol. 6 , no. 4 , pp. 1512-1519 . https://doi.org/10.1364/BOE.6.001512 | en |
dc.identifier.issn | 2156-7085 | |
dc.identifier.other | ORCID: /0000-0003-3422-3387/work/34730422 | |
dc.identifier.other | ORCID: /0000-0002-2977-4929/work/33493305 | |
dc.identifier.other | ORCID: /0000-0003-4218-2984/work/60195313 | |
dc.identifier.uri | https://hdl.handle.net/10023/6435 | |
dc.description | The authors thank the UK Engineering and Physical Sciences Research Council under grant EP/J01771X/1. | en |
dc.description.abstract | We demonstrate a miniaturized single beam fiber optical trapping probe based on a high numerical aperture graded index (GRIN) micro-objective lens. This enables optical trapping at a distance of 200μm from the probe tip. The fiber trapping probe is characterized experimentally using power spectral density analysis and an original approach based on principal component analysis for accurate particle tracking. Its use for biomedical microscopy is demonstrated through optically mediated immunological synapse formation. | |
dc.format.extent | 607478 | |
dc.language.iso | eng | |
dc.relation.ispartof | Biomedical Optics Express | en |
dc.subject | QC Physics | en |
dc.subject | NDAS | en |
dc.subject.lcc | QC | en |
dc.title | Development of a graded index microlens based fiber optical trap and its characterization using principal component analysis | en |
dc.type | Journal article | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.institution | University of St Andrews. School of Physics and Astronomy | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.identifier.doi | 10.1364/BOE.6.001512 | |
dc.description.status | Peer reviewed | en |
dc.identifier.grantnumber | EP/J01771X/1 | en |
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