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dc.contributor.advisorKamer, Paul (Paul C. J.)
dc.contributor.authorSamuels, Michiel C.
dc.coverage.spatialvii, 115 p.en_US
dc.date.accessioned2015-03-26T14:58:16Z
dc.date.available2015-03-26T14:58:16Z
dc.date.issued2014-06-25
dc.identifieruk.bl.ethos.640808
dc.identifier.urihttp://hdl.handle.net/10023/6357
dc.description.abstractCatalysis plays a key role in chemical conversions by making them faster and more selective. Despite its widespread use and decades of academic and industrial research, limited catalyst selectivity and stability still call for major improvements in catalyst performance to meet the demands of a sustainable society. Phosphine ligands are ubiquitous in transition metal chemistry and lead to extremely reactive and versatile homogeneous catalysts. Fast development of tailor-made catalysts and catalyst recovery are key issues in (asymmetric) homogeneous catalysis. Therefore libraries of ligands have to be synthesised and screened in an efficient way, which could be facilitated by Solid Phase Synthesis (SPS). Currently, most polymer bound ligands are anchored to the support after the synthesis in solution. However, the main advantages of synthesising the ligands directly on the polymeric support are not only easy catalyst recycling and product separation, but also the ease of purification during the synthesis steps, namely by simple washing and filtration. The use of SPS is very efficient for high throughput synthesis and screening of ligand libraries, however applications of SPS towards libraries of phosphorus ligands are rare, because the synthetic methodologies are still lacking. Here we present the development of methodologies towards novel immobilised bis(phosphine) ligands synthesised on polystyrene and JandaJel™ resin. By performing the synthesis steps on a solid support, the advantages of SPS are fully utilised. Successful routes have been developed towards immobilised secondary phosphine-boranes, which were versatile synthons to prepare a variety of new polymer-supported (C-chiral) bis(phosphine) ligands. These ligands were then tested for their catalytic activity in rhodium catalysed hydrogenation reactions.en_US
dc.language.isoenen_US
dc.publisherUniversity of St Andrews
dc.relationM. C. Samuels, B. H. G. Swennenhuis, P. C. J. Kamer, (2012), In Phosphorus(III) Ligands in Homogeneous Catalysis: Design and Synthesis; (Eds. P. C. J. Kamer, P. W. N. M. van Leeuwen), John Wiley & Sons, Ltd, Chichester, UK, pp. 463-479.en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectSolid phase synthesisen_US
dc.subjectImmobiliseden_US
dc.subject(Bis)phosphineen_US
dc.subjectDiphosphineen_US
dc.subjectChiralen_US
dc.subjectLiganden_US
dc.subjectAsymmetricen_US
dc.subjectCatalysisen_US
dc.subjectHydrogenationen_US
dc.subjectRhodiumen_US
dc.subjectOrganometallicen_US
dc.subject.lccQD412.P1S2
dc.subject.lcshOrganophosphorus compounds--Synthesisen_US
dc.subject.lcshSolid-phase synthesisen_US
dc.subject.lcshLigandsen_US
dc.titleSolid phase strategies for the preparation of phosphorus ligand librariesen_US
dc.typeThesisen_US
dc.type.qualificationlevelDoctoralen_US
dc.type.qualificationnamePhD Doctor of Philosophyen_US
dc.publisher.institutionThe University of St Andrewsen_US
dc.publisher.departmentSchool of Chemistryen_US


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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
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