A Clean and Selective Radical Homocoupling Employing Carboxylic Acids with Titania Photoredox Catalysis
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A titania photoredox catalysis protocol was developed for the homocoupling of C-centered radicals derived from carboxylic acids. Intermolecular reactions were generally efficient and selective, furnishing the desired dimers in good yields under mild neutral conditions. Selective cross-coupling with two acids proved unsuccessful. An intramolecular adaptation enabled macrocycles to be prepared, albeit in modest yields.
Manley , D W & Walton , J C 2014 , ' A Clean and Selective Radical Homocoupling Employing Carboxylic Acids with Titania Photoredox Catalysis ' Organic Letters , vol 16 , no. 20 , pp. 5394-5397 . DOI: 10.1021/ol502625w
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