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dc.contributor.authorZuleger, Nikolaj
dc.contributor.authorBoyle, Shelagh
dc.contributor.authorKelly, David A
dc.contributor.authorde Las Heras, Jose I
dc.contributor.authorLazou, Vassiliki
dc.contributor.authorKorfali, Nadia
dc.contributor.authorBatrakou, Dzmitry G
dc.contributor.authorRandles, K Natalie
dc.contributor.authorMorris, Glenn E
dc.contributor.authorHarrison, David J
dc.contributor.authorBickmore, Wendy A
dc.contributor.authorSchirmer, Eric C
dc.date.accessioned2015-03-13T15:31:08Z
dc.date.available2015-03-13T15:31:08Z
dc.date.issued2013-02-15
dc.identifier.citationZuleger , N , Boyle , S , Kelly , D A , de Las Heras , J I , Lazou , V , Korfali , N , Batrakou , D G , Randles , K N , Morris , G E , Harrison , D J , Bickmore , W A & Schirmer , E C 2013 , ' Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery ' , Genome Biology , vol. 14 , no. 2 , R14 . https://doi.org/10.1186/gb-2013-14-2-r14en
dc.identifier.issn1465-6906
dc.identifier.otherPURE: 173393287
dc.identifier.otherPURE UUID: 010c3c2b-853d-42c2-af54-5270d3323e85
dc.identifier.otherRIS: urn:ABBD38898420DB59F8568E427B153EF4
dc.identifier.otherScopus: 84873721028
dc.identifier.otherORCID: /0000-0001-9041-9988/work/64034203
dc.identifier.urihttp://hdl.handle.net/10023/6228
dc.description.abstractBACKGROUND: Different cell types have distinctive patterns of chromosome positioning in the nucleus. Although ectopic affinity-tethering of specific loci can be used to relocate chromosomes to the nuclear periphery, endogenous nuclear envelope proteins that control such a mechanism in mammalian cells have yet to be widely identified. RESULTS: To search for such proteins twenty three nuclear envelope transmembrane proteins were screened for their ability to promote peripheral localization of human chromosomes in HT1080 fibroblasts. Five of these proteins had strong effects on chromosome 5, but individual proteins affected different subsets of chromosomes. The repositioning effects were reversible and the proteins with effects all exhibited highly tissue-restricted patterns of expression. Depletion of two nuclear envelope transmembrane proteins that were preferentially expressed in liver each reduced the normal peripheral positioning of chromosome 5 in liver cells. CONCLUSIONS: The discovery of nuclear envelope transmembrane proteins that can modulate chromosome position and have restricted patterns of expression may enable dissection of the functional relevance of tissue-specific patterns of radial chromosome positioning.
dc.format.extent20
dc.language.isoeng
dc.relation.ispartofGenome Biologyen
dc.rights© 2013 Zuleger et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectGeneticsen
dc.titleSpecific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear peripheryen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.identifier.doihttps://doi.org/10.1186/gb-2013-14-2-r14
dc.description.statusPeer revieweden


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