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The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis

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dc.contributor.authorHowell, Kate J
dc.contributor.authorWeinert, Lucy A
dc.contributor.authorChaudhuri, Roy R
dc.contributor.authorLuan, Shi-Lu
dc.contributor.authorPeters, Sarah E
dc.contributor.authorCorander, Jukka
dc.contributor.authorHarris, David
dc.contributor.authorAngen, Øystein
dc.contributor.authorAragon, Virginia
dc.contributor.authorBensaid, Albert
dc.contributor.authorWilliamson, Susanna M
dc.contributor.authorParkhill, Julian
dc.contributor.authorLangford, Paul R
dc.contributor.authorRycroft, Andrew N
dc.contributor.authorWren, Brendan W
dc.contributor.authorHolden, Matthew T
dc.contributor.authorTucker, Alexander W
dc.contributor.authorMaskell, Duncan J
dc.date.accessioned2015-02-05T15:01:03Z
dc.date.available2015-02-05T15:01:03Z
dc.date.issued2014-12-24
dc.identifier.citationHowell , K J , Weinert , L A , Chaudhuri , R R , Luan , S-L , Peters , S E , Corander , J , Harris , D , Angen , Ø , Aragon , V , Bensaid , A , Williamson , S M , Parkhill , J , Langford , P R , Rycroft , A N , Wren , B W , Holden , M T , Tucker , A W & Maskell , D J 2014 , ' The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis ' , BMC Genomics , vol. 15 , 1179 . https://doi.org/10.1186/1471-2164-15-1179en
dc.identifier.issn1471-2164
dc.identifier.otherPURE: 161271760
dc.identifier.otherPURE UUID: 8316ec60-afe2-4600-8583-357ed0cd050d
dc.identifier.otherPubMed: 25539682
dc.identifier.otherScopus: 84939568343
dc.identifier.otherORCID: /0000-0002-4958-2166/work/60196365
dc.identifier.otherWOS: 000209598200001
dc.identifier.urihttps://hdl.handle.net/10023/6074
dc.descriptionThis work was supported by a BPEX PhD studentship and a Longer and Larger (LoLa) grant from the Biotechnology and Biological Sciences Research Council (grant numbers BB/G020744/1, BB/G019177/1, BB/G019274/1 and BB/G003203/1), the UK Department for Environment, Food and Rural Affairs and Zoetis, awarded to the Bacterial Respiratory Diseases of Pigs-1 Technology (BRaDP1T) consortium.en
dc.description.abstractHaemophilus parasuis is the etiologic agent of Glasser's disease in pigs and causes devastating losses to the farming industry. Whilst some hyper-virulent isolates have been described, the relationship between genetics and disease outcome has been only partially established. In particular, there is weak correlation between serovar and disease phenotype. We sequenced the genomes of 212 isolates of H. parasuis and have used this to describe the pan-genome and to correlate this with clinical and carrier status, as well as with serotype.
dc.language.isoeng
dc.relation.ispartofBMC Genomicsen
dc.rights© 2014 Howell et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.subjectGenome wide association studyen
dc.subjectPan-genomeen
dc.subjectRecombinationen
dc.subjectDAPCen
dc.subjectVirulence factorsen
dc.subjectPopulation structureen
dc.subjectHaemophilus parasuisen
dc.subjectQH301 Biologyen
dc.subjectQR Microbiologyen
dc.subject.lccQH301en
dc.subject.lccQRen
dc.titleThe use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuisen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Infection Groupen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1186/1471-2164-15-1179
dc.description.statusPeer revieweden
dc.identifier.urlhttp://www.biomedcentral.com/1471-2164/15/1179/abstracten


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