The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis
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Haemophilus parasuis is the etiologic agent of Glasser's disease in pigs and causes devastating losses to the farming industry. Whilst some hyper-virulent isolates have been described, the relationship between genetics and disease outcome has been only partially established. In particular, there is weak correlation between serovar and disease phenotype. We sequenced the genomes of 212 isolates of H. parasuis and have used this to describe the pan-genome and to correlate this with clinical and carrier status, as well as with serotype.
Howell , K J , Weinert , L A , Chaudhuri , R R , Luan , S-L , Peters , S E , Corander , J , Harris , D , Angen , Ø , Aragon , V , Bensaid , A , Williamson , S M , Parkhill , J , Langford , P R , Rycroft , A N , Wren , B W , Holden , M T , Tucker , A W & Maskell , D J 2014 , ' The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis ' BMC Genomics , vol 15 , 1179 . DOI: 10.1186/1471-2164-15-1179
© 2014 Howell et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
This work was supported by a BPEX PhD studentship and a Longer and Larger (LoLa) grant from the Biotechnology and Biological Sciences Research Council (grant numbers BB/G020744/1, BB/G019177/1, BB/G019274/1 and BB/G003203/1), the UK Department for Environment, Food and Rural Affairs and Zoetis, awarded to the Bacterial Respiratory Diseases of Pigs-1 Technology (BRaDP1T) consortium.
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