A cooperative Pd-Cu system for direct C-H bond arylation
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A novel and efficient method for C-H arylation using well-defined Pd- and Cu-NHC systems has been developed. This process promotes the challenging construction of C-C bonds from arenes or heteroarenes using aryl bromides and chlorides. Mechanistic studies show that [Cu(OH)(NHC)] plays a key role in the C-H activation and is involved in the transmetallation with the Pd-NHC co-catalyst.
Lesieur , M , Lazreg , F & Cazin , C S J 2014 , ' A cooperative Pd-Cu system for direct C-H bond arylation ' Chemical Communications , vol 50 , no. 64 , pp. 8927-8929 . DOI: 10.1039/c4cc03201b
Copyright 2014 The Authors. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/)
The authors are grateful to the Royal Society (University Research Fellowship to CSJC) for financial support.