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Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration : a systematic review and economic evaluation

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dc.contributor.authorMowatt, G.
dc.contributor.authorHernández, R.
dc.contributor.authorCastillo, M.
dc.contributor.authorLois, N.
dc.contributor.authorElders, A.
dc.contributor.authorFraser, C.
dc.contributor.authorAremu, O.
dc.contributor.authorAmoaku, W.
dc.contributor.authorBurr, J.
dc.contributor.authorLotery, A.
dc.contributor.authorRamsay, C.
dc.contributor.authorAzuara-Blanco, A.
dc.date.accessioned2015-01-19T16:31:04Z
dc.date.available2015-01-19T16:31:04Z
dc.date.issued2014-11
dc.identifier.citationMowatt , G , Hernández , R , Castillo , M , Lois , N , Elders , A , Fraser , C , Aremu , O , Amoaku , W , Burr , J , Lotery , A , Ramsay , C & Azuara-Blanco , A 2014 , ' Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration : a systematic review and economic evaluation ' , Health Technology Assessment , vol. 18 , no. 69 , pp. 1-253 . https://doi.org/10.3310/hta18690en
dc.identifier.issn1366-5278
dc.identifier.otherPURE: 159576087
dc.identifier.otherPURE UUID: 0aae5721-7d97-4c89-95b5-14d05e9e69c2
dc.identifier.otherScopus: 84913525336
dc.identifier.otherWOS: 000346706300001
dc.identifier.otherORCID: /0000-0002-9478-738X/work/60196187
dc.identifier.urihttps://hdl.handle.net/10023/6025
dc.description.abstractResults: In pooled estimates of diagnostic studies (all TD-OCT), sensitivity and specificity [95% confidence interval (CI)] was 88% (46% to 98%) and 78% (64% to 88%) respectively. For monitoring, the pooled sensitivity and specificity (95% CI) was 85% (72% to 93%) and 48% (30% to 67%) respectively. The FFA for diagnosis and nurse-technician-led monitoring strategy had the lowest cost (£39,769; QALYs 10.473) and dominated all others except FFA for diagnosis and ophthalmologist-led monitoring (£44,649; QALYs 10.575; incremental cost-effectiveness ratio £47,768). The least costly strategy had a 46.4% probability of being cost-effective at £30,000 willingness-to-pay threshold.
dc.format.extent253
dc.language.isoeng
dc.relation.ispartofHealth Technology Assessmenten
dc.rights© Queen’s Printer and Controller of HMSO 2014. This work was produced by Mowatt et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising.en
dc.subjectR Medicine (General)en
dc.subject.lccR1en
dc.titleOptical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration : a systematic review and economic evaluationen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.identifier.doihttps://doi.org/10.3310/hta18690
dc.description.statusPeer revieweden


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