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Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration : a systematic review and economic evaluation

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dc.contributor.authorMowatt, G.
dc.contributor.authorHernández, R.
dc.contributor.authorCastillo, M.
dc.contributor.authorLois, N.
dc.contributor.authorElders, A.
dc.contributor.authorFraser, C.
dc.contributor.authorAremu, O.
dc.contributor.authorAmoaku, W.
dc.contributor.authorBurr, J.
dc.contributor.authorLotery, A.
dc.contributor.authorRamsay, C.
dc.contributor.authorAzuara-Blanco, A.
dc.date.accessioned2015-01-19T16:31:04Z
dc.date.available2015-01-19T16:31:04Z
dc.date.issued2014-11
dc.identifier159576087
dc.identifier0aae5721-7d97-4c89-95b5-14d05e9e69c2
dc.identifier84913525336
dc.identifier000346706300001
dc.identifier.citationMowatt , G , Hernández , R , Castillo , M , Lois , N , Elders , A , Fraser , C , Aremu , O , Amoaku , W , Burr , J , Lotery , A , Ramsay , C & Azuara-Blanco , A 2014 , ' Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration : a systematic review and economic evaluation ' , Health Technology Assessment , vol. 18 , no. 69 , pp. 1-253 . https://doi.org/10.3310/hta18690en
dc.identifier.issn1366-5278
dc.identifier.otherORCID: /0000-0002-9478-738X/work/60196187
dc.identifier.urihttps://hdl.handle.net/10023/6025
dc.description.abstractResults: In pooled estimates of diagnostic studies (all TD-OCT), sensitivity and specificity [95% confidence interval (CI)] was 88% (46% to 98%) and 78% (64% to 88%) respectively. For monitoring, the pooled sensitivity and specificity (95% CI) was 85% (72% to 93%) and 48% (30% to 67%) respectively. The FFA for diagnosis and nurse-technician-led monitoring strategy had the lowest cost (£39,769; QALYs 10.473) and dominated all others except FFA for diagnosis and ophthalmologist-led monitoring (£44,649; QALYs 10.575; incremental cost-effectiveness ratio £47,768). The least costly strategy had a 46.4% probability of being cost-effective at £30,000 willingness-to-pay threshold.
dc.format.extent253
dc.format.extent2481891
dc.language.isoeng
dc.relation.ispartofHealth Technology Assessmenten
dc.subjectR Medicine (General)en
dc.subject.lccR1en
dc.titleOptical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration : a systematic review and economic evaluationen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.identifier.doihttps://doi.org/10.3310/hta18690
dc.description.statusPeer revieweden


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