Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration : a systematic review and economic evaluation
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Results: In pooled estimates of diagnostic studies (all TD-OCT), sensitivity and specificity [95% confidence interval (CI)] was 88% (46% to 98%) and 78% (64% to 88%) respectively. For monitoring, the pooled sensitivity and specificity (95% CI) was 85% (72% to 93%) and 48% (30% to 67%) respectively. The FFA for diagnosis and nurse-technician-led monitoring strategy had the lowest cost (£39,769; QALYs 10.473) and dominated all others except FFA for diagnosis and ophthalmologist-led monitoring (£44,649; QALYs 10.575; incremental cost-effectiveness ratio £47,768). The least costly strategy had a 46.4% probability of being cost-effective at £30,000 willingness-to-pay threshold.
Mowatt , G , Hernández , R , Castillo , M , Lois , N , Elders , A , Fraser , C , Aremu , O , Amoaku , W , Burr , J , Lotery , A , Ramsay , C & Azuara-Blanco , A 2014 , ' Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration : a systematic review and economic evaluation ' Health Technology Assessment , vol 18 , no. 69 , pp. 1-253 . DOI: 10.3310/hta18690
Health Technology Assessment
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