Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration : a systematic review and economic evaluation
Abstract
Results: In pooled estimates of diagnostic studies (all TD-OCT), sensitivity and specificity [95% confidence interval (CI)] was 88% (46% to 98%) and 78% (64% to 88%) respectively. For monitoring, the pooled sensitivity and specificity (95% CI) was 85% (72% to 93%) and 48% (30% to 67%) respectively. The FFA for diagnosis and nurse-technician-led monitoring strategy had the lowest cost (£39,769; QALYs 10.473) and dominated all others except FFA for diagnosis and ophthalmologist-led monitoring (£44,649; QALYs 10.575; incremental cost-effectiveness ratio £47,768). The least costly strategy had a 46.4% probability of being cost-effective at £30,000 willingness-to-pay threshold.
Citation
Mowatt , G , Hernández , R , Castillo , M , Lois , N , Elders , A , Fraser , C , Aremu , O , Amoaku , W , Burr , J , Lotery , A , Ramsay , C & Azuara-Blanco , A 2014 , ' Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration : a systematic review and economic evaluation ' , Health Technology Assessment , vol. 18 , no. 69 , pp. 1-253 . https://doi.org/10.3310/hta18690
Publication
Health Technology Assessment
Status
Peer reviewed
ISSN
1366-5278Type
Journal article
Rights
© Queen’s Printer and Controller of HMSO 2014. This work was produced by Mowatt et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising.
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