2-Arylacetic anhydrides as ammonium enolate precursors

View/Open
Smith_2014_OBC_2Arylacetic_AM.pdf (1.424Mb)
Date
28/01/2014
Author
Keywords
Metadata
Show full item record
Abstract
Readily prepared 2-arylacetic anhydrides act as convenient ammonium enolate precursors in isothiourea (HBTM-2.1)-mediated catalytic asymmetric intermolecular Michael addition-lactonisation processes, giving diverse synthetic building blocks in good yield with high diastereo- and enantiocontrol (up to 98 : 2 dr and > 99% ee).
Citation
Morrill , L C , Ledingham , L A , Couturier , J-P , Bickel , J , Harper , A D , Fallan , C & Smith , A D 2014 , ' 2-Arylacetic anhydrides as ammonium enolate precursors ' Organic & Biomolecular Chemistry , vol. 12 , no. 4 , pp. 624-636 . DOI: 10.1039/c3ob41869c
Publication
Organic & Biomolecular Chemistry
Status
Peer reviewed
DOI
https://doi.org/10.1039/c3ob41869c
ISSN
1477-0520
Type
Journal article
Rights
© Royal Society of Chemistry 2014. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at http://dx.doi.org/10.1039/C3OB41869C
Description
This work is supported by funding from the Carnegie Trust for the Universities of Scotland and EPSRC
Collections
URI
http://hdl.handle.net/10023/5916

Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.