2-Arylacetic anhydrides as ammonium enolate precursors
Abstract
Readily prepared 2-arylacetic anhydrides act as convenient ammonium enolate precursors in isothiourea (HBTM-2.1)-mediated catalytic asymmetric intermolecular Michael addition-lactonisation processes, giving diverse synthetic building blocks in good yield with high diastereo- and enantiocontrol (up to 98 : 2 dr and > 99% ee).
Citation
Morrill , L C , Ledingham , L A , Couturier , J-P , Bickel , J , Harper , A D , Fallan , C & Smith , A D 2014 , ' 2-Arylacetic anhydrides as ammonium enolate precursors ' , Organic & Biomolecular Chemistry , vol. 12 , no. 4 , pp. 624-636 . https://doi.org/10.1039/c3ob41869c
Publication
Organic & Biomolecular Chemistry
Status
Peer reviewed
ISSN
1477-0520Type
Journal article
Description
This work is supported by funding from the Carnegie Trust for the Universities of Scotland and EPSRCCollections
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