2-Arylacetic anhydrides as ammonium enolate precursors
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Readily prepared 2-arylacetic anhydrides act as convenient ammonium enolate precursors in isothiourea (HBTM-2.1)-mediated catalytic asymmetric intermolecular Michael addition-lactonisation processes, giving diverse synthetic building blocks in good yield with high diastereo- and enantiocontrol (up to 98 : 2 dr and > 99% ee).
Morrill , L C , Ledingham , L A , Couturier , J-P , Bickel , J , Harper , A D , Fallan , C & Smith , A D 2014 , ' 2-Arylacetic anhydrides as ammonium enolate precursors ' Organic & Biomolecular Chemistry , vol 12 , no. 4 , pp. 624-636 . DOI: 10.1039/c3ob41869c
Organic & Biomolecular Chemistry
© Royal Society of Chemistry 2014. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at http://dx.doi.org/10.1039/C3OB41869C
DescriptionThis work is supported by funding from the Carnegie Trust for the Universities of Scotland and EPSRC
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