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Multirate delivery of multiple therapeutic agents from metal-organic frameworks

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dc.contributor.authorMcKinlay, Alistair Craig
dc.contributor.authorAllan, Phoebe
dc.contributor.authorRenouf, Catherine Louise
dc.contributor.authorDuncan, Morven Jane
dc.contributor.authorWheatley, Paul Stewart
dc.contributor.authorWarrender, Stewart James
dc.contributor.authorDawson, Daniel McLean
dc.contributor.authorAshbrook, Sharon Elizabeth
dc.contributor.authorGil, Barbara
dc.contributor.authorMarszalek, Bartosz
dc.contributor.authorDüren, Tina
dc.contributor.authorWilliams, Jennifer J.
dc.contributor.authorCharrier, Cedric
dc.contributor.authorMercer, Derry K.
dc.contributor.authorTeat, Simon J.
dc.contributor.authorMorris, Russell Edward
dc.date.accessioned2014-12-11T11:01:03Z
dc.date.available2014-12-11T11:01:03Z
dc.date.issued2014-12
dc.identifier.citationMcKinlay , A C , Allan , P , Renouf , C L , Duncan , M J , Wheatley , P S , Warrender , S J , Dawson , D M , Ashbrook , S E , Gil , B , Marszalek , B , Düren , T , Williams , J J , Charrier , C , Mercer , D K , Teat , S J & Morris , R E 2014 , ' Multirate delivery of multiple therapeutic agents from metal-organic frameworks ' , APL Materials , vol. 2 , no. 12 , 124108 . https://doi.org/10.1063/1.4903290en
dc.identifier.issn2166-532X
dc.identifier.otherPURE: 159434650
dc.identifier.otherPURE UUID: 4a726a68-485c-4b46-9b07-30cc210e37bb
dc.identifier.otherWOS: 000347170700015
dc.identifier.otherScopus: 84916942040
dc.identifier.otherORCID: /0000-0002-4538-6782/work/56638967
dc.identifier.otherORCID: /0000-0002-8110-4535/work/34029116
dc.identifier.otherORCID: /0000-0001-7809-0315/work/61622119
dc.identifier.urihttps://hdl.handle.net/10023/5913
dc.descriptionREM is a Royal Society Industry Fellow and thanks the Royal Society for the provision of the Brian Mercer Award for Innovation, and thanks Scottish Enterprise for support. REM also thanks the British Heart Foundation for a New Horizons Award (NH/11/8/29253). REM and TD thank the EPSRC for funding (EP/K025112/1 and EP/K005499/1).en
dc.description.abstractThe highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.
dc.language.isoeng
dc.relation.ispartofAPL Materialsen
dc.rights© 2014 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/)en
dc.subjectQD Chemistryen
dc.subject.lccQDen
dc.titleMultirate delivery of multiple therapeutic agents from metal-organic frameworksen
dc.typeJournal articleen
dc.contributor.sponsorEPSRCen
dc.contributor.sponsorEPSRCen
dc.contributor.sponsorBritish Councilen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doihttps://doi.org/10.1063/1.4903290
dc.description.statusPeer revieweden
dc.identifier.grantnumberEP/K005499/1en
dc.identifier.grantnumberEP/K025112/1en
dc.identifier.grantnumberNH/11/8/29253en


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