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Multirate delivery of multiple therapeutic agents from metal-organic frameworks

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Morris_2014_APlMat_Multirate.pdf (2.367Mb)
Date
12/2014
Author
McKinlay, Alistair Craig
Allan, Phoebe
Renouf, Catherine Louise
Duncan, Morven Jane
Wheatley, Paul Stewart
Warrender, Stewart James
Dawson, Daniel McLean
Ashbrook, Sharon Elizabeth
Gil, Barbara
Marszalek, Bartosz
Düren, Tina
Williams, Jennifer J.
Charrier, Cedric
Mercer, Derry K.
Teat, Simon J.
Morris, Russell Edward
Keywords
QD Chemistry
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Abstract
The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.
Citation
McKinlay , A C , Allan , P , Renouf , C L , Duncan , M J , Wheatley , P S , Warrender , S J , Dawson , D M , Ashbrook , S E , Gil , B , Marszalek , B , Düren , T , Williams , J J , Charrier , C , Mercer , D K , Teat , S J & Morris , R E 2014 , ' Multirate delivery of multiple therapeutic agents from metal-organic frameworks ' , APL Materials , vol. 2 , no. 12 , 124108 . https://doi.org/10.1063/1.4903290
Publication
APL Materials
Status
Peer reviewed
DOI
https://doi.org/10.1063/1.4903290
ISSN
2166-532X
Type
Journal article
Rights
© 2014 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/)
Description
REM is a Royal Society Industry Fellow and thanks the Royal Society for the provision of the Brian Mercer Award for Innovation, and thanks Scottish Enterprise for support. REM also thanks the British Heart Foundation for a New Horizons Award (NH/11/8/29253). REM and TD thank the EPSRC for funding (EP/K025112/1 and EP/K005499/1).
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/5913

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