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dc.contributor.authorMacqueen, Daniel J.
dc.contributor.authorGarcia de la Serrana Castillo, Daniel
dc.contributor.authorJohnston, Ian Alistair
dc.date.accessioned2014-11-17T14:31:01Z
dc.date.available2014-11-17T14:31:01Z
dc.date.issued2014-06-11
dc.identifier.citationMacqueen , D J , Garcia de la Serrana Castillo , D & Johnston , I A 2014 , ' Cardiac myoglobin deficit has evolved repeatedly in teleost fishes ' Biology Letters , vol. 10 , no. 6 , 20140225 . https://doi.org/10.1098/rsbl.2014.0225en
dc.identifier.issn1744-9561
dc.identifier.otherPURE: 155544425
dc.identifier.otherPURE UUID: bd8f4d3e-5e2a-431d-b04d-d96e22d74bda
dc.identifier.otherWOS: 000338351500007
dc.identifier.otherScopus: 84904490760
dc.identifier.otherORCID: /0000-0002-7796-5754/work/47136030
dc.identifier.otherWOS: 000338351500007
dc.identifier.urihttp://hdl.handle.net/10023/5776
dc.descriptionThis study was supported by the Marine Alliance for Science and Technology for Scotland (Scottish Funding Council grant no. HR09011),en
dc.description.abstractMyoglobin (Mb) is the classic vertebrate oxygen-binding protein present in aerobic striated muscles. It functions principally in oxygen delivery and provides muscle with its characteristic red colour. Members of the Antarctic icefish family (Channichthyidae) are widely thought to be extraordinary for lacking cardiac Mb expression, a fact that has been attributed to their low metabolic rate and unusual evolutionary history. Here, we report that cardiac Mb deficit, associated with pale heart colour, has evolved repeatedly during teleost evolution. This trait affects both gill-and air-breathing species from temperate to tropical habitats across a full range of salinities. Cardiac Mb deficit results from total pseudogenization in three-spined stickleback and is associated with a massive reduction in mRNA level in two species that evidently retain functional Mb. The results suggest that near or complete absence of Mb-assisted oxygen delivery to heart muscle is a common facet of teleost biodiversity, even affecting lineages with notable oxygen demands. We suggest that Mb deficit may affect how different teleost species deal with increased tissue oxygen demands arising under climate change.
dc.format.extent5
dc.language.isoeng
dc.relation.ispartofBiology Lettersen
dc.rights© 2014. The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.en
dc.subjectMyoglobinen
dc.subjectOxygen supplyen
dc.subjectFish evolutionen
dc.subjectClimate changeen
dc.subjectThermal toleranceen
dc.subjectLimitationen
dc.subjectExpressionen
dc.subjectOxygenen
dc.subjectQH301 Biologyen
dc.subject.lccQH301en
dc.titleCardiac myoglobin deficit has evolved repeatedly in teleost fishesen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Marine Alliance for Science & Technology Scotlanden
dc.contributor.institutionUniversity of St Andrews.Scottish Oceans Instituteen
dc.contributor.institutionUniversity of St Andrews.Centre for Research into Ecological & Environmental Modellingen
dc.identifier.doihttps://doi.org/10.1098/rsbl.2014.0225
dc.description.statusPeer revieweden


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