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Cardiac myoglobin deficit has evolved repeatedly in teleost fishes

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Macqueen2010biollett20140225.pdf (698.7Kb)
Date
11/06/2014
Author
Macqueen, Daniel J.
Garcia de la Serrana Castillo, Daniel
Johnston, Ian Alistair
Keywords
Myoglobin
Oxygen supply
Fish evolution
Climate change
Thermal tolerance
Limitation
Expression
Oxygen
QH301 Biology
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Abstract
Myoglobin (Mb) is the classic vertebrate oxygen-binding protein present in aerobic striated muscles. It functions principally in oxygen delivery and provides muscle with its characteristic red colour. Members of the Antarctic icefish family (Channichthyidae) are widely thought to be extraordinary for lacking cardiac Mb expression, a fact that has been attributed to their low metabolic rate and unusual evolutionary history. Here, we report that cardiac Mb deficit, associated with pale heart colour, has evolved repeatedly during teleost evolution. This trait affects both gill-and air-breathing species from temperate to tropical habitats across a full range of salinities. Cardiac Mb deficit results from total pseudogenization in three-spined stickleback and is associated with a massive reduction in mRNA level in two species that evidently retain functional Mb. The results suggest that near or complete absence of Mb-assisted oxygen delivery to heart muscle is a common facet of teleost biodiversity, even affecting lineages with notable oxygen demands. We suggest that Mb deficit may affect how different teleost species deal with increased tissue oxygen demands arising under climate change.
Citation
Macqueen , D J , Garcia de la Serrana Castillo , D & Johnston , I A 2014 , ' Cardiac myoglobin deficit has evolved repeatedly in teleost fishes ' , Biology Letters , vol. 10 , no. 6 , 20140225 . https://doi.org/10.1098/rsbl.2014.0225
Publication
Biology Letters
Status
Peer reviewed
DOI
https://doi.org/10.1098/rsbl.2014.0225
ISSN
1744-9561
Type
Journal article
Rights
© 2014. The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.
Description
This study was supported by the Marine Alliance for Science and Technology for Scotland (Scottish Funding Council grant no. HR09011),
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/5776

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