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dc.contributor.authorThomson, Nicholas R.
dc.contributor.authorHoward, Sarah
dc.contributor.authorWren, Brendan W.
dc.contributor.authorHolden, Matthew T. G.
dc.contributor.authorCrossman, Lisa
dc.contributor.authorChallis, Gregory L.
dc.contributor.authorChurcher, Carol
dc.contributor.authorMungall, Karen
dc.contributor.authorBrooks, Karen
dc.contributor.authorChillingworth, Tracey
dc.contributor.authorFeltwell, Theresa
dc.contributor.authorAbdellah, Zahra
dc.contributor.authorHauser, Heidi
dc.contributor.authorJagels, Kay
dc.contributor.authorMaddison, Mark
dc.contributor.authorMoule, Sharon
dc.contributor.authorSanders, Mandy
dc.contributor.authorWhitehead, Sally
dc.contributor.authorQuail, Michael A.
dc.contributor.authorDougan, Gordon
dc.contributor.authorParkhill, Julian
dc.contributor.authorPrentice, Michael B.
dc.identifier.citationThomson , N R , Howard , S , Wren , B W , Holden , M T G , Crossman , L , Challis , G L , Churcher , C , Mungall , K , Brooks , K , Chillingworth , T , Feltwell , T , Abdellah , Z , Hauser , H , Jagels , K , Maddison , M , Moule , S , Sanders , M , Whitehead , S , Quail , M A , Dougan , G , Parkhill , J & Prentice , M B 2006 , ' The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081 ' , PLoS Genetics , vol. 2 , no. 12 , 206 , pp. 2039-2051 .
dc.identifier.otherPURE: 91779069
dc.identifier.otherPURE UUID: 1ef6ae1e-d9a4-4b66-80f8-fd99dd5e9ec3
dc.identifier.otherWOS: 000243482100009
dc.identifier.otherScopus: 33845999944
dc.identifier.otherORCID: /0000-0002-4958-2166/work/60196434
dc.descriptionThis work was supported by The Wellcome Trust.en
dc.description.abstractThe human enteropathogen, Yersinia enterocolitica, is a significant link in the range of Yersinia pathologies extending from mild gastroenteritis to bubonic plague. Comparison at the genomic level is a key step in our understanding of the genetic basis for this pathogenicity spectrum. Here we report the genome of Y. enterocolitica strain 8081 (serotype 0: 8; biotype 1B) and extensive microarray data relating to the genetic diversity of the Y. enterocolitica species. Our analysis reveals that the genome of Y. enterocolitica strain 8081 is a patchwork of horizontally acquired genetic loci, including a plasticity zone of 199 kb containing an extraordinarily high density of virulence genes. Microarray analysis has provided insights into species-specific Y. enterocolitica gene functions and the intraspecies differences between the high, low, and nonpathogenic Y. enterocolitica biotypes. Through comparative genome sequence analysis we provide new information on the evolution of the Yersinia. We identify numerous loci that represent ancestral clusters of genes potentially important in enteric survival and pathogenesis, which have been lost or are in the process of being lost, in the other sequenced Yersinia lineages. Our analysis also highlights large metabolic operons in Y. enterocolitica that are absent in the related enteropathogen, Yersinia pseudotuberculosis, indicating major differences in niche and nutrients used within the mammalian gut. These include clusters directing, the production of hydrogenases, tetrathionate respiration, cobalamin synthesis, and propanediol utilisation. Along with ancestral gene clusters, the genome of Y. enterocolitica has revealed species-specific and enteropathogen-specific loci. This has provided important insights into the pathology of this bacterium and, more broadly, into the evolution of the genus. Moreover, wider investigations looking at the patterns of gene loss and gain in the Yersinia have highlighted common themes in the genome evolution of other human enteropathogens.
dc.relation.ispartofPLoS Geneticsen
dc.rights© 2006 Thomson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectOsmoregulated periplasmic glucansen
dc.subjectMethionine salvage pathwayen
dc.subjectIII secretionen
dc.subjectEvolutionary genomicsen
dc.subjectBacterial pathogensen
dc.subjectQH426 Geneticsen
dc.titleThe complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081en
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Infection Groupen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.description.statusPeer revieweden

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