Time is of the essence for ParaHox homeobox gene clustering.
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ParaHox genes, and their evolutionary sisters the Hox genes, are integral to patterning the anterior-posterior axis of most animals. Like the Hox genes, ParaHox genes can be clustered and exhibit the phenomenon of colinearity - gene order within the cluster matching gene activation. Two new instances of ParaHox clustering provide the first examples of intact clusters outside chordates, with gene expression lending weight to the argument that temporal colinearity is the key to understanding clustering.
Garstang , M G & Ferrier , D E K 2013 , ' Time is of the essence for ParaHox homeobox gene clustering. ' BMC Biology , vol 11 , no. 72 , 72 . DOI: 10.1186/1741-7007-11-72
Non peer reviewed
© 2013 Garstang and Ferrier; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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