Files in this item
A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation
Item metadata
dc.contributor.author | Zhang, Qingzhi | |
dc.contributor.author | Kulczynska, Agnieszka | |
dc.contributor.author | Webb, David J. | |
dc.contributor.author | Megson, Ian L. | |
dc.contributor.author | Botting, Nigel P. | |
dc.date.accessioned | 2013-08-05T15:31:05Z | |
dc.date.available | 2013-08-05T15:31:05Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Zhang , Q , Kulczynska , A , Webb , D J , Megson , I L & Botting , N P 2013 , ' A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation ' , Chemical Communications , vol. 49 , no. 14 , pp. 1389-1391 . https://doi.org/10.1039/c2cc38382a | en |
dc.identifier.issn | 1359-7345 | |
dc.identifier.other | PURE: 62954742 | |
dc.identifier.other | PURE UUID: fab48fee-25c3-4270-80a4-1c5d673de794 | |
dc.identifier.other | WOS: 000313805700005 | |
dc.identifier.other | Scopus: 84872738180 | |
dc.identifier.uri | http://hdl.handle.net/10023/3918 | |
dc.description | The authors are grateful to the Wellcome Trust (Catalyst Biomedica Development Award 063729/Z/01/Z) for financial support. | en |
dc.description.abstract | This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of gamma-glutamyl transpeptidase (gamma-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF). | |
dc.format.extent | 3 | |
dc.language.iso | eng | |
dc.relation.ispartof | Chemical Communications | en |
dc.rights | © Royal Society of Chemistry 2013. This is an open access article, available from http://pubs.rsc.org | en |
dc.subject | Nitric-oxide synthases | en |
dc.subject | Cardiac-surgery | en |
dc.subject | rat-kidney | en |
dc.subject | Injury | en |
dc.subject | Hydroxyguanidines | en |
dc.subject | Failure | en |
dc.subject | Oxidation | en |
dc.subject | Strategy | en |
dc.subject | Prodrugs | en |
dc.subject | DOPA | en |
dc.subject | QD Chemistry | en |
dc.subject.lcc | QD | en |
dc.title | A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation | en |
dc.type | Journal article | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1039/c2cc38382a | |
dc.description.status | Peer reviewed | en |
This item appears in the following Collection(s)
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.