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A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

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dc.contributor.authorZhang, Qingzhi
dc.contributor.authorKulczynska, Agnieszka
dc.contributor.authorWebb, David J.
dc.contributor.authorMegson, Ian L.
dc.contributor.authorBotting, Nigel P.
dc.date.accessioned2013-08-05T15:31:05Z
dc.date.available2013-08-05T15:31:05Z
dc.date.issued2013
dc.identifier.citationZhang , Q , Kulczynska , A , Webb , D J , Megson , I L & Botting , N P 2013 , ' A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation ' , Chemical Communications , vol. 49 , no. 14 , pp. 1389-1391 . https://doi.org/10.1039/c2cc38382aen
dc.identifier.issn1359-7345
dc.identifier.otherPURE: 62954742
dc.identifier.otherPURE UUID: fab48fee-25c3-4270-80a4-1c5d673de794
dc.identifier.otherWOS: 000313805700005
dc.identifier.otherScopus: 84872738180
dc.identifier.urihttp://hdl.handle.net/10023/3918
dc.descriptionThe authors are grateful to the Wellcome Trust (Catalyst Biomedica Development Award 063729/Z/01/Z) for financial support.en
dc.description.abstractThis communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of gamma-glutamyl transpeptidase (gamma-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).
dc.format.extent3
dc.language.isoeng
dc.relation.ispartofChemical Communicationsen
dc.rights© Royal Society of Chemistry 2013. This is an open access article, available from http://pubs.rsc.orgen
dc.subjectNitric-oxide synthasesen
dc.subjectCardiac-surgeryen
dc.subjectrat-kidneyen
dc.subjectInjuryen
dc.subjectHydroxyguanidinesen
dc.subjectFailureen
dc.subjectOxidationen
dc.subjectStrategyen
dc.subjectProdrugsen
dc.subjectDOPAen
dc.subjectQD Chemistryen
dc.subject.lccQDen
dc.titleA new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatationen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1039/c2cc38382a
dc.description.statusPeer revieweden


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