A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation
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This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of gamma-glutamyl transpeptidase (gamma-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).
Zhang , Q , Kulczynska , A , Webb , D J , Megson , I L & Botting , N P 2013 , ' A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation ' Chemical Communications , vol 49 , no. 14 , pp. 1389-1391 . DOI: 10.1039/c2cc38382a
© Royal Society of Chemistry 2013. This is an open access article, available from http://pubs.rsc.org
DescriptionThe authors are grateful to the Wellcome Trust (Catalyst Biomedica Development Award 063729/Z/01/Z) for financial support.
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