A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

Zhang, Qingzhi; Kulczynska, Agnieszka; Webb, David J.; Megson, Ian L.; Botting, Nigel P.

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Date

2013

Abstract

This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of gamma-glutamyl transpeptidase (gamma-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

Citation

Zhang , Q , Kulczynska , A , Webb , D J , Megson , I L & Botting , N P 2013 , ' A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation ' , Chemical Communications , vol. 49 , no. 14 , pp. 1389-1391 . https://doi.org/10.1039/c2cc38382a

Publication

Chemical Communications

Status

Peer reviewed

DOI

https://doi.org/10.1039/c2cc38382a

ISSN

1359-7345

Type

Journal article

Rights

Description

The authors are grateful to the Wellcome Trust (Catalyst Biomedica Development Award 063729/Z/01/Z) for financial support.

Collections

University of St Andrews Research

URI

http://hdl.handle.net/10023/3918