A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

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Date
2013
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Abstract
This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of gamma-glutamyl transpeptidase (gamma-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).
Citation
Zhang , Q , Kulczynska , A , Webb , D J , Megson , I L & Botting , N P 2013 , ' A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation ' Chemical Communications , vol. 49 , no. 14 , pp. 1389-1391 . DOI: 10.1039/c2cc38382a
Publication
Chemical Communications
Status
Peer reviewed
DOI
https://doi.org/10.1039/c2cc38382a
ISSN
1359-7345
Type
Journal article
Rights
© Royal Society of Chemistry 2013. This is an open access article, available from http://pubs.rsc.org
Description
The authors are grateful to the Wellcome Trust (Catalyst Biomedica Development Award 063729/Z/01/Z) for financial support.
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URI
http://hdl.handle.net/10023/3918

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