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An enzymatic route to selenazolines

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dc.contributor.authorKoehnke, Jesko
dc.contributor.authorMorawitz, Falk
dc.contributor.authorBent, Andrew F.
dc.contributor.authorHoussen, Wael E.
dc.contributor.authorShirran, Sally L.
dc.contributor.authorFuszard, Matthew A.
dc.contributor.authorSmellie, Iain A.
dc.contributor.authorBotting, Catherine H.
dc.contributor.authorSmith, Margaret C. M.
dc.contributor.authorJaspars, Marcel
dc.contributor.authorNaismith, James H.
dc.date.accessioned2013-08-05T12:01:02Z
dc.date.available2013-08-05T12:01:02Z
dc.date.issued2013-03-18
dc.identifier50487746
dc.identifierea84f969-b4e1-4144-b0a9-c46a329c7094
dc.identifier000316285600003
dc.identifier84875038064
dc.identifier.citationKoehnke , J , Morawitz , F , Bent , A F , Houssen , W E , Shirran , S L , Fuszard , M A , Smellie , I A , Botting , C H , Smith , M C M , Jaspars , M & Naismith , J H 2013 , ' An enzymatic route to selenazolines ' , ChemBioChem , vol. 14 , no. 5 , pp. 564-567 . https://doi.org/10.1002/cbic.201300037en
dc.identifier.issn1439-4227
dc.identifier.otherORCID: /0000-0003-3516-3507/work/32169115
dc.identifier.otherORCID: /0000-0002-5829-6487/work/34028574
dc.identifier.urihttps://hdl.handle.net/10023/3907
dc.descriptionSupported by a Wellcome Trust Capital Award (086036)en
dc.description.abstractRinging the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines.
dc.format.extent4
dc.format.extent250882
dc.language.isoeng
dc.relation.ispartofChemBioChemen
dc.subjectPatellamidesen
dc.subjectMacrocyclizationen
dc.subjectDerivativesen
dc.subjectBiochemistryen
dc.subjectLineen
dc.subjectBiosynthesisen
dc.subjectSelenazolinesen
dc.subjectQD Chemistryen
dc.subject.lccQDen
dc.titleAn enzymatic route to selenazolinesen
dc.typeJournal articleen
dc.contributor.sponsorBBSRCen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doi10.1002/cbic.201300037
dc.description.statusPeer revieweden
dc.identifier.grantnumberBB/K015508/1en


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