An enzymatic route to selenazolines
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Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines.
Koehnke , J , Morawitz , F , Bent , A F , Houssen , W E , Shirran , S L , Fuszard , M A , Smellie , I A , Botting , C H , Smith , M C M , Jaspars , M & Naismith , J H 2013 , ' An enzymatic route to selenazolines ' , ChemBioChem , vol. 14 , no. 5 , pp. 564-567 . https://doi.org/10.1002/cbic.201300037
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article.
DescriptionSupported by a Wellcome Trust Capital Award (086036)
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