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dc.contributor.authorRobinson, Emily R. T.
dc.contributor.authorFallan, Charlene
dc.contributor.authorSimal, Carmen
dc.contributor.authorSlawin, Alexandra M. Z.
dc.contributor.authorSmith, Andrew D.
dc.date.accessioned2013-07-31T23:49:26Z
dc.date.available2013-07-31T23:49:26Z
dc.date.issued2013
dc.identifier.citationRobinson , E R T , Fallan , C , Simal , C , Slawin , A M Z & Smith , A D 2013 , ' Anhydrides as α,β-unsaturated acyl ammonium precursors : isothiourea-promoted catalytic asymmetric annulation processes ' Chemical Science , vol 4 , pp. 2193-2200 . DOI: 10.1039/c3sc50199jen
dc.identifier.issn2041-6520
dc.identifier.otherPURE: 61811299
dc.identifier.otherPURE UUID: f82782d8-0c2b-425a-a510-aa7266e8ef87
dc.identifier.otherWOS: 000316966500034
dc.identifier.urihttp://hdl.handle.net/10023/3901
dc.description.abstractThe asymmetric annulation of a range of alpha,beta-unsaturated acyl ammonium intermediates, formed from isothiourea HBTM 2.1 and anhydrides with either 1,3-dicarbonyls, beta-ketoesters or azaaryl ketones gives either functionalised esters (upon ring opening), dihydropyranones or dihydropyridones in good yields (up to 93%) and high enantioselectivity (up to 97% ee).en
dc.format.extent8en
dc.language.isoeng
dc.relation.ispartofChemical Scienceen
dc.rights© Royal Society of Chemistry 2013. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.en
dc.subjectBicyclic-beta-lactonesen
dc.subjectSecondary benzylic alcoholsen
dc.subjectDynamic kinetic resolutionen
dc.subjectN-heterocyclic carbenesen
dc.subjectSilyl ketene acetalsen
dc.subjectLewis-base catalysisen
dc.subjectEnantioselective synthesisen
dc.subjectQD Chemistryen
dc.subject.lccQDen
dc.titleAnhydrides as α,β-unsaturated acyl ammonium precursors : isothiourea-promoted catalytic asymmetric annulation processesen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doihttp://dx.doi.org/10.1039/c3sc50199j
dc.description.statusPeer revieweden


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