Anhydrides as α,β-unsaturated acyl ammonium precursors : isothiourea-promoted catalytic asymmetric annulation processes
MetadataShow full item record
The asymmetric annulation of a range of alpha,beta-unsaturated acyl ammonium intermediates, formed from isothiourea HBTM 2.1 and anhydrides with either 1,3-dicarbonyls, beta-ketoesters or azaaryl ketones gives either functionalised esters (upon ring opening), dihydropyranones or dihydropyridones in good yields (up to 93%) and high enantioselectivity (up to 97% ee).
Robinson , E R T , Fallan , C , Simal , C , Slawin , A M Z & Smith , A D 2013 , ' Anhydrides as α,β-unsaturated acyl ammonium precursors : isothiourea-promoted catalytic asymmetric annulation processes ' Chemical Science , vol 4 , pp. 2193-2200 . DOI: 10.1039/c3sc50199j
© Royal Society of Chemistry 2013. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.