The synthesis of natural and novel glucosinolates
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This thesis describes the synthesis of natural and novel glucosinolates 1.Chapter 1 gives an overview of glucosinolates, from isolation and biosynthesis to previous chemical syntheses. Chapter 2 describes an improved method for the formation of thiohydroximate bonds and its application over a variey of substrates. Chapter 3 focuses on exploring new chemistry on intact glucoinolates and details oxidative chemistry on an alkene containing side chain glucosinolate. Futhermore, the total synthesis of novel glucosinolates 150, 156 and 161 is illustrated.Chapter 4 describes a model study for the solid phase synthesis of glucosinolates. Finally experimental procedures for the compounds synthesised in the thesis are described in Chapter 5.
Thesis, PhD Doctor of Philosophy
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