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Overcoming limited selectivity in recognition-mediated replicating systems
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dc.contributor.advisor | Philp, Douglas | |
dc.contributor.author | MacKenzie, Harry | |
dc.coverage.spatial | xiii, 201 | en_US |
dc.date.accessioned | 2013-06-07T13:25:58Z | |
dc.date.available | 2013-06-07T13:25:58Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | https://hdl.handle.net/10023/3633 | |
dc.description.abstract | Traditionally, synthetic chemistry has always focused on yielding a target compound from the linear application of chemical transformations. After each step, a single compound is usually required and the presence of mixtures often demands lengthy purification prior to the next synthetic step. The emerging field of systems chemistry aims to study the currently under-exploited science of networks and complex mixtures. Through the chemistry of reversible chemical bonds, dynamic covalent chemistry (DCC), the creation of networks of compounds linked through a plethora of equilibrium processes, termed dynamic combinatorial libraries (DCLs), is possible. In this research, a DCL based on imine/nitrone exchange is designed and presented. The DCL is subsequently coupled to an irreversible chemical reaction based on molecular recognition and the dramatic responses observed within the DCL are discussed. The properties of the dynamic systems developed during the course of this research are then applied to the competition between emerging self-replicators in an attempt to demonstrate Darwinian Evolution. A thorough discussion of the inherent limitations placed upon a system by kinetic selection is presented in the context of self-replicators. Finally, non-linear chemical dynamics are discussed and successfully incorporated into a competitive replication scenario. The application of reaction diffusion fronts allows a self-replicating system to break the stranglehold of kinetic selection and exhibit its dominance over weaker competitors. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of St Andrews | |
dc.subject.lcc | QD503.K4 | |
dc.subject.lcsh | Chemical systems | en_US |
dc.subject.lcsh | Chemical systems--Evolution | en_US |
dc.subject.lcsh | Autopoesis | en_US |
dc.subject.lcsh | Molecular recognition | en_US |
dc.title | Overcoming limited selectivity in recognition-mediated replicating systems | en_US |
dc.type | Thesis | en_US |
dc.type.qualificationlevel | Doctoral | en_US |
dc.type.qualificationname | MPhil Master of Philosophy | en_US |
dc.publisher.institution | The University of St Andrews | en_US |
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