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dc.contributor.authorGradin, Victoria
dc.contributor.authorWaiter, Gordon
dc.contributor.authorO'Connor, Akira Robert
dc.contributor.authorRomaniuk, Liana
dc.contributor.authorStickle, Catriona
dc.contributor.authorMatthews, Keith
dc.contributor.authorHall, Jeremy
dc.contributor.authorSteele, Douglas
dc.identifier.citationGradin , V , Waiter , G , O'Connor , A R , Romaniuk , L , Stickle , C , Matthews , K , Hall , J & Steele , D 2013 , ' Salience network-midbrain dysconnectivity and blunted reward signals in schizophrenia ' , Psychiatry Research: Neuroimaging , vol. 211 , no. 2 , pp. 104-111 .
dc.identifier.otherPURE: 22707539
dc.identifier.otherPURE UUID: 9160d452-ee99-48d3-a447-3d2a0c4c292b
dc.identifier.otherScopus: 84873447602
dc.identifier.otherORCID: /0000-0002-7943-5183/work/34028970
dc.description.abstractTheories of schizophrenia propose that abnormal functioning of the neural reward system is linked to negative and psychotic symptoms, by disruption of reward processing and promotion of context-independent false associations. Recently it has been argued that an insula-anterior cingulate cortex (ACC) salience network system enables switching of brain states from the default mode to a task-related activity mode. Abnormal interaction between the insula-ACC system and reward processing regions may help explain abnormal reinforcer processing and symptoms. Here we use fMRI to assess the neural correlates of reward processing in schizophrenia. Furthermore we investigated functional connectivity between the dopaminergic midbrain, a key region for the processing of reinforcers, and other brain regions. In response to rewards, controls activated task related regions (striatum, amygdala/hippocampus and midbrain) and the insula-ACC salience network. Patients similarly activated the insula-ACC salience network system but failed to activate task related regions. Reduced functional connectivity between the midbrain and the insula was found in schizophrenia, with the extent of this abnormality correlating with increased psychotic symptoms. The findings support the notion that reward processing is abnormal in schizophrenia and highlight the potential role of abnormal interactions between the insula-ACC salience network and reward regions.
dc.relation.ispartofPsychiatry Research: Neuroimagingen
dc.rightsThis is an author version of this work. The published version (c) 2012 Elsevier Ireland Ltd is available from www.sciencedirect.comen
dc.subjectReward processingen
dc.subjectSalience networken
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.titleSalience network-midbrain dysconnectivity and blunted reward signals in schizophreniaen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.description.statusPeer revieweden

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