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Salience network-midbrain dysconnectivity and blunted reward signals in schizophrenia

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Gradin_et_al_Psychiatry_Research_Neuroimaging_2012.pdf (4.082Mb)
Date
28/02/2013
Author
Gradin, Victoria
Waiter, Gordon
O'Connor, Akira Robert
Romaniuk, Liana
Stickle, Catriona
Matthews, Keith
Hall, Jeremy
Steele, Douglas
Keywords
Schizophrenia
fMRI
Reward processing
Connectivity
Salience network
Midbrain
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
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Abstract
Theories of schizophrenia propose that abnormal functioning of the neural reward system is linked to negative and psychotic symptoms, by disruption of reward processing and promotion of context-independent false associations. Recently it has been argued that an insula-anterior cingulate cortex (ACC) salience network system enables switching of brain states from the default mode to a task-related activity mode. Abnormal interaction between the insula-ACC system and reward processing regions may help explain abnormal reinforcer processing and symptoms. Here we use fMRI to assess the neural correlates of reward processing in schizophrenia. Furthermore we investigated functional connectivity between the dopaminergic midbrain, a key region for the processing of reinforcers, and other brain regions. In response to rewards, controls activated task related regions (striatum, amygdala/hippocampus and midbrain) and the insula-ACC salience network. Patients similarly activated the insula-ACC salience network system but failed to activate task related regions. Reduced functional connectivity between the midbrain and the insula was found in schizophrenia, with the extent of this abnormality correlating with increased psychotic symptoms. The findings support the notion that reward processing is abnormal in schizophrenia and highlight the potential role of abnormal interactions between the insula-ACC salience network and reward regions.
Citation
Gradin , V , Waiter , G , O'Connor , A R , Romaniuk , L , Stickle , C , Matthews , K , Hall , J & Steele , D 2013 , ' Salience network-midbrain dysconnectivity and blunted reward signals in schizophrenia ' , Psychiatry Research: Neuroimaging , vol. 211 , no. 2 , pp. 104-111 . https://doi.org/10.1016/j.pscychresns.2012.06.003
Publication
Psychiatry Research: Neuroimaging
Status
Peer reviewed
DOI
https://doi.org/10.1016/j.pscychresns.2012.06.003
ISSN
0925-4927
Type
Journal article
Rights
This is an author version of this work. The published version (c) 2012 Elsevier Ireland Ltd is available from www.sciencedirect.com
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/3245

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